Haematological Profile in Neonatal Septiceamia
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2017, Vol 16, Issue 4
Abstract
Background: Neonatal septicemia is defined as a bacterial infection documemted by positive blood culture in first four weeks of life. The early sepsis screen is vital as it detect earlier & enable the clinician to treat the infection timely & adequately, which in turn help to reduce the neonatal morbidity & mortality. AIMS & Objective: To study changes in hematological parameter in neonatal septicemia. To compare the positive predictive valve of hematological test with respective to clinical respond. Material & Methods: The Study Was Conducted In Kakatiya Medical College/Mahatma Gandhi Hospital, Warangal, Telangana. During the period of two year, from jan-2014 to dec 2016.ninety four neonates below the age 28days with suspected septicemia were included in the study. Neonates were admitted & sepsis screen (total leucocytic count, band forms, toxic granules, micro-ESR,C-reactive protein) was done. Result: 53(56.4%) male babies were affected by neonatal septicemia. Male to female Ratio was 1.3: 1. Early onset septicemia was present in 82.8% terms babies and 86% babies with normal birth weight Commonly observed clinical manifestations in our study were refusal of Feeds (56%), temperature abnormality (46%), Pallor (36%), not doing well (24%), rash (20%) and convulsions (16%). Sepsis screen was studied in bacteriologically positive and negative cases. Combination of C-reactive protein and toxic granulation had 63.3% sensitivity, specificity of 70.8%, and 40% positive predictive accuracy. Combination of C-reactive protein and platelet count had 36.3% sensitivity, specificity of 70.8% and 27.5% positive predictive accuracy. Conclusion: Sepsis screen has good sensitivity, specificity and positive predictive Accuracy and is a valuable aid in early diagnosis of neonatal septicemia. Sepsis screen is simple, cheap, less time consuming and easy to perform even at bedside. As an individual test C-reactive protein has highest sensitivity, specificity and positive predictive accuracy and is a sensitive and responsive indicator of neonatal sepsis. Combination of tests increases the specificity and positive predictive accuracy.
Authors and Affiliations
Dr. G. Vandana, Dr. S. Lokesh rao magar, Dr. Praveen, Dr. B . Kavita devi, Dr. sandhya rani, Dr. sandhya anil
Keywords
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