Haematological scoring system- a diagnostic tool for neonatal sepsis. How reliable is it?
Journal Title: IP Journal of Diagnostic Pathology and Oncology - Year 2018, Vol 3, Issue 3
Abstract
Introduction Neonatal septicaemia is the important cause for mortality and morbidity Early diagnosis helps in timely intervention and favorable outcome Although blood culture is gold standard it has low sensitivity and delays the diagnosis Hence formulation of rapid diagnostic tools that can indicate sepsis at earlier stage is importantObjective To evaluate performance of each parameter in the Hematological scoring system 40HSS41 in diagnosis of neonatal sepsisMaterials and Methods Blood samples from 130 clinically suspected neonates were subjected to sepsis screening tests Differential count was performed on the peripheral smear to obtain immature cell count Hematological scoring was performed The sensitivity specificity positive predictive value PPV and negative predictive value NPV were calculated for each of the parameter with blood culture as Gold StandardResults Out of 130 sepsis suspected neonates 354 showed culture positivity Total polymorphonuclear count had highest sensitivity 896 and NPV 843 and immature to mature PMN count IM 03 had highest specificity 100and PPV100 HSS with the combination of two test being positive score 2 gave good sensitivity 100 and NPV 100 but low specificity 547 and PPV 547 Specificity and PPV increased with increase in the HSSConclusion No parameters can be taken alone as indicator of sepsis Total PMN count was the sensitive indicator but lacks specificity HSS score of Keywords Neonatal sepsis Haematological scoring system Blood culture Immature polymorphonuclear cells
Authors and Affiliations
Rajashree K, Jayaprakash C. S.
Keywords
Related Articles
- EP ID EP482781
- DOI 10.18231/2581-3706.2018.0045
- Views 88
- Downloads 0
Evaluation of clinicopathological parameters and its relation with immunohistochemical expressions in breast carcinoma: A hospital based cross-sectional observational study
Introduction Knowhow of HER2neu protooncogene amplification andor over expression and presence of hormone estrogen and progesterone receptors in tumour tissue is one of the most crucial checkpoints in the therapy of brea...
Sudden cardiac death: An autopsy study
Introduction The most common cause of sudden cardiac death is ischaemic Such patients may have an occlusive recent thrombosis in one or more major coronary arteries An area of stenosis of 85 per cent is the best discrimi...
Study of vesicobullous lesions of the skin clinical and histopathology correlation
Introduction Vesiculobullous diseases are a group of disorders in which primary lesion is a vesicle or a bulla on the skin or mucous membrane or both Though some of the veisculobullous lesions are characteristics in thei...
Xanthogranulomatous Pyelonephritis in association with Chronic kidney disease: A novel step in early detection of Renal Tuberculosis
Introduction: Xanthogranulomatous pyelonephritis is a chronic renal pathological condition with destructive granulomatous process. It is typically associated with nephrolithiasis followed by sequelae of nonfunctioning ki...
A Study of atherosclerotic lesions of aorta with CD4 immunostaining
Indian population is affected with atherosclerosis at younger age when compared to other ethnic groups In this study histopathological grading of atherosclerotic lesions of the ascending aorta in archival specimens were...