Haemodynamic Effects during Induction in Cervical Spine Injuries Patients: Comparison of Three Drug Dose Combinations of Ketamine and Propofol
Journal Title: Journal of Medical Science And clinical Research - Year 2016, Vol 4, Issue 1
Abstract
Background and Aims: Cervical spine injured patients have bradycardia & hypotension, which may be aggravated during induction of anaesthesia. Very few studies are available regarding this problem. Studies are available where propofol and ketamine or propofol and ephedrine are used to maintain cardiovascular stability but these too are limited to normal population. We decided to compare the haemodynamic parameters during induction with three different drug dose combinations of propofol and ketamine to know the best drug dose combination of these two drugs for haemodynamic stability in cervical spine injury patients. Methods: We studied 60 adult patients of either sex with established cervical spine injury with quadriplegia scheduled to undergo elective surgical procedures under general anesthesia and randomly divided into 3 groups. Data was collected by measuring Pulse rate, Systolic Blood Pressure, Diastolic Blood Pressure & Mean Blood Pressure. The results: Haemodynamic changes in group PK (propofol 1.0 mg/kg + ketamine 1.0 mg/kg) were less than the group PPK (propofol 1.5 mg/kg + ketamine 0.5 mg/kg) but more as compared to PKK (propofol 0.5 mg/kg + ketamine 1.5 mg/kg). Conclusion: To avoid haemodynamic changes during induction of anesthesia in cervical spine injury patients, drug dose combination of PKK (propofol 0.5 mg/kg + ketamine 1.5 mg/kg) should be preferred over PPK (propofol 1.5 mg/kg + ketamine 0.5 mg/kg).
Authors and Affiliations
Dr Ravinder Dhanerwa
Keywords
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