Haemophilia B
Journal Title: Journal of Medical Sciences - Year 2016, Vol 19, Issue 1
Abstract
Haemophilia is a group of inherited blood disorders in which blood does not clot properly. Bleeding disorders are due to defect in blood vessels, the coagulation mechanism or the blood platelets. Blood coagulation mechanism is a process which transforms blood from a liquid into solid and involves different clotting factors that generate fibrin fibers through extrinsic or intrinsic coagulation pathway which along with platelet plug stops bleeding. When coagulation factors are deficient, the blood does not clot properly and bleeding continues. An affected individual may bleed spontaneously or for longer than a healthy person after injury or surgery. Haemophilia is an X-linked recessive disorder that affects males, and females are protected by normal gene on other X-chromosome. Queen Victoria was a carrier of haemophilia and passed the mutation to her son Leopold and through her daughters to members of Royal families of Spain, Russia, and Germany.
Authors and Affiliations
Neena Sharma, Sabita Yograj
Keywords
Related Articles
- EP ID EP433693
- DOI -
- Views 53
- Downloads 0
SPRINT: More Intensive Blood Pressure Management Saves Lives
A more intensive strategy of blood pressure management reduces the risk for death and cardiovascular events when compared with a strategy that lowers systolic blood pressure to the conventional target of 140 mm Hg, a lar...
POLYSOMNOGRAPHY
Polysomnography (PSG) is the gold standard diagnostic test for several sleep disorders. It records, analyzes, & interprets multiple simultaneous physiologic characteristics during sleep. These parameters include brain wa...
Adenosquamous Carcinoma of Ampulla of Vater: A Case Report and Review of Literature
Background: Adenosquamous carcinomas are very rare tumors of the ampulla of Vater with only seven cases reported in literature. Case report: We report a case of adenosquamous carcinoma in a 40-ye...
Radiation Protection in Pediatric Radiology
The radiation risk is higher for children than for adults, as children's tissues have a higher cell division rate, and cells can be damaged during this process. Children's bodies also have a higher water content and ther...
Effect of metformin on thyrotropin levels in treatment-naive type 2 diabetes and related traits
INTRODUCTION: Metformin is the drug of choice for initiating treatment in type 2 DM, recently it has been found that metformin also suppresses TSH. We also tried to study this thyroidal effect of metformin. METHODS: We...