Half a century of IgA nephropathy: achievements, frustrations and challenges
Journal Title: УКРАЇНСЬКИЙ ЖУРНАЛ НЕФРОЛОГІЇ ТА ДІАЛІЗУ - Year 2018, Vol 3, Issue 59
Abstract
IgA nephropathy is the most common glomerulonephritis worldwide. This disease has a tremendous economic impact because renal replacement therapy is expensive and hard-to-reach. It also represents a social problem because children and young adults in their second and third decades of life are affected by the IgA nephropathy, and it is the most active period of human life with highest work productivity. Many retrospective studies have shown that 40% of biopsy-proven IgA nephropathy patients develop end-stage kidney disease in 20 years after their biopsy disease. The biomarker research in IgA nephropathy has experienced a major splash in recent years with great number of scientific reports. Individual biomarkers often lack sensitivity and specificity with impairment of disease specificity as a consequence. The review describes a novel approach based on a panel of biomarkers for pathogenic process of IgA nephropathy. Integration of genetic, clinical, and bioinformatics data sets could optimize the specific value of each biomarker in a multimarker panel. This is a inspirational and promising approach for precision medicine and personalized therapy in IgA nephropathy. Half a century into the original description of IgA nephropathy, there is still no specific therapy for this condition Although the scarcity in treatment advances could be related to the disease’s complex pathogenesis. The evolution of different therapeutic approaches is reviewed over time and resulted in the 2012 Kidney Disease: Improving Global Outcomes Clinical Practice Guideline for Glomerulonephritis that presently is being updated, and provide collation of recent data on various forms of immunosuppressive agents. Existing approaches to treatment of IgA nephropathy are described with focus primarily on innovative therapeutic strategies currently being evaluated in IgA nephropathy that were not discussed in the 2012 Kidney Disease Improving Global Outcomes Clinical Practice Guidelines.
Authors and Affiliations
I. I. Lapchynska
Keywords
Related Articles
- EP ID EP414702
- DOI 10.31450/ukrjnd.3(59).2018.08
- Views 75
- Downloads 0
The evaluation of residual kidney function in patients with ckd vd and approaches of its preservation
The work is a literature review. Residual kidney function (RKF) is one of the crucial indicators of mortality and quality of life in patients with chronic kidney disease. Residual renal function provides better control o...
РИЗИК ЗНИЖЕННЯ LACTOBACILLUS SPP. У СКЛАДІ МІКРОБІОТИ КИШКІВНИКА ХВОРИХ НА ІНФЕКЦІЮ СЕЧОВОЇ СИСТЕМИ, АСОЦІОЙВАНИЙ З ПРИЙОМОМ АНТИБАКТЕРІАЛЬНИХ ЛІКАРСЬКИХ ЗАСОБІВ
Метою нашої роботи було оцінити ризик зниження індигенної мікробіоти кішківника хворих на інфекцію сечової системи (ІСС), асоційований з прийомом антибактеріальних лікарських засобів. Матеріал та методи. До ретроспектив...
Structural, functional and endothelial peculiarities of diabetic nephropathy in patients with arterial hypertension
The aim of our one-stage observational study was the detail analysis of structural, functional, endothelial peculiarities of diabetic nephropathy in patients with coexistent arterial hypertension. Methods. Our study inv...
ПРЕДИКТОРИ ХРОНІЧНОЇ ХВОРОБИ НИРОК У ПАЦІЄНТІВ, ІНФІКОВАНИХ ВІРУСОМ ІМУНОДЕФІЦИТУ ЛЮДИНИ
Мета роботи: встановити частоту діагностики та предиктори хронічної хвороби нирок у ВІЛ- інфікованих пацієнтів. Пацієнти та методи. Обстежено 292хворих на ВІЛ-інфекцією, які перебували на амбулаторному спостереженні в Ч...
The relationship between the dose of continuous erythropoietin receptor activator and oxidative stress in hemodialysis patients
At present, there have been no reports on the dose-dependent effects of continuous erythropoietin receptor activator(CERA) therapy on oxidative stress and red blood cell membrane lipid peroxidation parameters in hemodial...