Haplotype based association study between t-PA gene and essential hypertension
Journal Title: International Journal of Biomedical Science (IJBS) - Year 2006, Vol 2, Issue 2
Abstract
Several previous studies have shown that essential hypertension (EH) is associated with fibrinolysis. Tissue plasminogen activator (t-PA) plays a key role in fibrinolysis. Thus, it is possible that the t-PA gene is a susceptibility gene of EH. However, there have been no reported studies of association between EH and the t-PA gene using single nucleotide polymorphisms (SNPs). The aim of the present haplotype-based case-control study was to investigate whether SNPs in the human t-PA gene are associated with EH. We performed a genetic association study using 3 SNPs (rs7007329, rs8178750, rs4471024). The subjects were 276 EH patients and 283 age-matched normotensive (NT) individuals. There were no significant differences in overall distribution of genotypes or alleles between EH patients and NT subjects. Also, there were no significant differences in the haplotype-based case-control study. The present results do not indicate an association between the t-PA gene and EH. How to cite this article: Int. J. Biomed. Sci. 2006; 2(2):166-1171 For full text article or PDF file, visit: www.ijbs.org
Authors and Affiliations
Kosuke Saito, Tomohiro Nakayama, Naoyuki Sato, Ron Usami, Yoshiyuki Kaneko, Ichiro Sato, Akihiko Morita, Teruyuki Takahashi, Masayoshi Soma
Keywords
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