harmacokinetics and bioavailability of difloxacin in camel
Journal Title: Journal of Veterinary Medical Research - Year 2005, Vol 15, Issue 2
Abstract
The pharmacokinetic profile of difloxacin was investigated in camels after single intravenous and intramuscular administration of 5 mg kg-1 b.wt. After i. v. injection, serum concentration time curve was best described as two compartment open model. The distribution and elimination half lives (t0.5 (') and t0.5())) were 0.513± 0.01 h and 6.3±0.15 h. respectively. Difloxacin was distributed extravascularly with a volume of distribution (Vdss) 1.10 ± 0.035 l kg-1., and total body clearance (CLB) of 0.141+ 0.031 l kg-1 h-1. following intramusclar injection, peak serum concentration (Cmax) 2.59 ± 0.19 ug ml-1 attained after Tmax 3.05 ± 0.035 h. The absorption and elimination half lives (t0.5 (ab) and t0.5 (el)) were 0.95 ± 0.003 and 5.86 ± 0.33 h., respectively. The systemic bioavailablility (F) and the plasma protein binding were 87.95 and 23 %, respectively.
Authors and Affiliations
M. A. Tohamy1; A. A. M. El- Gendy1; M. Ismail2 1Pharmacology Department, Faculty of Veterinary Medicine Beni-suef University, Beni-suef, Egypt 2Pharmacology Department, Faculty of Veterinary Medicine, Cairo University, Cairo, Egypt
Keywords
Related Articles
- EP ID EP682716
- DOI -
- Views 242
- Downloads 0
Antiviral activity of Curcuma longa against Newcastle disease virus (in vitro and in vivo studies)
The antiviral activity of Curcuma longa against NDV on vero cell culture and in infected chicken was observed. The obtained results showed that low concentration of Curcuma longa 0.25% did not produce cytotoxicity on the...
Monitoring and molecular characterization of multidrug resistant enteropathogenic E. coli in dairy calves and their environment
This study was performed to investigate the frequency and the distribution of antimicrobial resistance and resistant genes in enteropathogenic Escherichia coli (EPEC) isolated from both calves and their environment. Feca...
Abortion and shedding of Brucella abortus RB51 in vaginal exudates of vaccinated cows
In this study, Brucella abortus RB51 could be detected in the vaginal exudates of 5 out of 26 aborted cows following vaccination of three dairy cattle herds of 3810 animals including heifers and pregnant and non-pregna...
Pathogenicity of Aeromonas hydrophila isolated from diseased sharp teeth catfish, Clarias gariepinus, with special reference to the lethality of its extracellular products
A study was conducted to investigate the pathogenicity and the median lethal dose (LD50) of Aeromonas hydrophila isolated from clinically diseased catfish against apparently healthy homologous fish to evaluate the lethal...
Pharmacokinetic interaction of tulathromycin with Flunixin meglumine after intravenous injection in goats
The pharmacokinetic aspects of tulathromycin (2.5 mg/kg b.w.) were studied following intravenous administration alone and in combination with flunixin meglumine (2.2 mg/kg b.w) in apparently healthy goats. Tulathromycin...