Heart-type Fatty Acid-Binding Protein (H-FABP) as a Biochemical Marker to Differentiate Ischemic and Hemorrhagic Stroke
Journal Title: Indonesian Journal of Clinical Pharmacy - Year 2017, Vol 6, Issue 1
Abstract
Stroke is an acute neurological syndrome that occurs due to a decrease in blood flow caused by blocked or rupture of blood vessels of the brain (cerebrovascular) that causes damage to brain tissue. Based on the pathogenesis, there are two types of stroke, the ischemic and hemorrhagic stroke, in which the handling of treatment in both types of stroke are very different, so the differential diagnosis is required to distinguish the two types of stroke. The purpose of this study is to determine whether Heart-type Fatty Acid-Binding Protein (H-FABP) can be used as a parameter of biochemical marker to distinguish between ischemic and hemorrhagic stroke. H-FABP assay is performed using blood serum and analyzed by Enzyme Linked Immunosorbent Assay (ELISA) sandwich method, each using H-FABP test kit. Blood serum taken from 20 patients with ischemic strokes and 18 hemorrhagic stroke patients from one of a hospital in Jakarta. The results showed that the average H-FABP concentration in ischemic stroke-patients is 9,07 ng/mL and hemorrhagic stroke-patients is 18,54 ng/mL; statistically there are significant difference between H-FABP concentration in ischemic stroke-patients and hemorrhagic stroke-patients (α=0.05). Thus Heart-type Fatty Acid-Binding Protein (H-FABP) can be used as one of the parameters of biochemical markers to distinguish between ischemic and hemorrhagic stroke.
Authors and Affiliations
Eli Halimah, Evy Liswati, Erwin Sasmita
Keywords
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- EP ID EP369600
- DOI 10.15416/ijcp.2017.6.1.55
- Views 103
- Downloads 0
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