Heat Shock Protein 90 c-Terminal Inhibitors in Cancer Treatment
Journal Title: International Journal of Pharmaceutical Sciences and Developmental Research - Year 2015, Vol 1, Issue 1
Abstract
Heat shock protein 90 (Hsp90) is 90 kDa highly conserved dimeric chaperone protein in prokaryotic and eukaryotic cells and it is localized in different parts of the cell. Hsp90AA1 (inducible) and Hsp90AB1 (constitutive) are available in the cytosol; Grp94 and TRAP1 exist in endoplasmic reticulum and mitochondria; respectively. In unstressed cells, expression level of Hsp90 corresponds to 1-2% of total cellular protein, and Hsp90 is responsible for protein folding, maintenance and degradation of misfolded proteins, cell cycle control, and cellular signaling. Hsp90 is composed of three domains: N terminal domain (NTD), middle domain (MD), and C terminal domain (CTD). Hsp90 needs ATP hydrolysis energy to perform chaperone functions. NTD has ATP binding sites and ATP hydrolysis leads to large conformational changes for interaction between substrate proteins and Hsp90. CTD contains a conserved EEVD motif and the dimerization interface to regulate ATPase process and binding of co-chaperones (i.e. Hop, CHIP) in protein folding process [1-1. Tutar L, Tutar Y (2010) Heat shock proteins; an overview. Curr Pharm Biotechnol 11: 216-222.33. Li J, Soroka J, Buchner J (2012) The Hsp90 chaperone machinery: conformational dynamics and regulation by co-chaperones. Biochim Biophys Acta 1823: 624-635. ].
Authors and Affiliations
Tutar Yusuf
Keywords
Related Articles
- EP ID EP555588
- DOI 10.17352/ijpsdr.000001
- Views 42
- Downloads 0
Diabesity Increases Inflammation and Oxidative Stress
Background: Inflammation and oxidative stress are two pathophysiological mechanisms that link obesity, type 2 diabetes mellitus (T2DM) and diabesity. However how levels of inflammatory and oxidative stress markers differ...
JAK inhibitors: a promising direction for treating Rheumatoid Arthritis
Rheumatoid Arthritis (RA) is a chronic auto inflammatory disease that causes incapacitating changes both the musculoskeletal system and the internal organs [1]. Tumor Necrosis Factor inhibitors (TNFi) promised a new revo...
Synergistic Action in Oral Glucose Tolerance Tests between Spilanthes Calva Aerial Parts and Tubers of Colocasia Esculenta
Introduction: Diabetes is a debilitating disease characterized by elevated blood glucose levels, which is rapidly r eaching endemic proportions throughout the world including Bangladesh. We had previously evaluated the a...
Generation of Porous Structure from Basil Seed Mucilage via Supercritical Fluid Assisted Process for Biomedical Applications
Mucilage’s are plant derived natural polymer which are valuable due to their nontoxicity, low cost and nonirritating nature, with wide range of applications. In this work, extracted mucilage from basil seeds (BSM) was dr...
Comparative Chemical Composition of the Essential Oils from Hedyotis Diffusa WILLD and Hedyotis Corymbosa Lam by GC-MS
Introduction: Hedyotis diffusa Willd. (Baihuasheshecao) is an ingredient of herbal commonly consumed in China for cancer treatment and health maintenance. In the market, this ingredient is frequently adulterated by the r...