HELICOBACTER PYLORI INFECTION IN AMNIOTIC FLUID MAY CAUSE HYPEREMESIS GRAVIDARUM
Journal Title: International Journal Of Advances In Gynaecology - Year 2019, Vol 3, Issue 4
Abstract
OBJECTIVES: Limited data are avaible from recent trials involving pregnant women to guide the diagnosis of Helicobacter pylori infection. There is no data about presence of H. pylori in the amniotic fluid as well. Furthermore, relation between amniotic fluid H. pylori and hyperemesis gravidarum (HG) has not been characterized yet. MATERIALS AND METHODS: Pregnant women undergoing amniocentesis were enrolled in the study. Presence of H. pylori in amniotic fluid was assessed by stool antigen test. A perinatalogist independently performed amniocentesis. Obtained amniotic fluid was sent to the laboratory to assess H. pylori infection by stool H. pylori antigen assay. We determined the rate of H. pylori in amniotic fluid and assessed relations between H. pylori infection and pregnancy outcome including HG. RESULTS: Between May 2017 - September 2017, we enrolled 48 pregnant women who underwent amniocentesis to detect possible fetal malformations. Among them, 28 (58.3%) were found to have positive for H. pylori in the amniotic fluid. The rate of HG was significantly higher (71.4%) in patients who tested positive for H. pylori in amniocentesis than H. pylori negative group (20%), (p<0.001). CONCLUSIONS: The main new finding of the study is that presence of H. pylori in the amniotic fluid is possible. Our data suggest that H. pylori infected amniotic fluid is associated with experience of past HG. Current study may have important implications for detecting HG and may help identify patients who would derive the most benefit from future preventive strategies.
Authors and Affiliations
Sasmaz MI, Dulger AC, Ayvaz MA, Demir B, Tolunay HE
Keywords
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