Helicobacter Pylori specific antibodies among multiple sclerosis patients
Journal Title: Neurology Letters - Year 2022, Vol 1, Issue 1
Abstract
Background: Multiple sclerosis (MS) is one of the most common neurological diseases that occurs predominantly in young adults and more commonly in women. MS is a chronic inflammatory disease characterized by demyelinating lesions in the brain, spinal cord, and optic nerve. This study aimed to compare Helicobacter pylori infection in patients with MS and the control group.Methos: the study was case-control. And population consisted of patients referred to a neurological specialty clinic in Isfahan from 2015 to 2018, 107 cases in the case group and 107 in the control group. The case group was referred to causes such as headache, dizziness, and other diseases that had no established association with Helicobacter pylori. Case and control groups by referring to a laboratory through IgA and IgG antibodies against Helicobacter pylori were investigated.Results: The mean age in the case and control group was 32 years. The mean IgA in the case group was 17.03 and in the control group 29.25, which was statistically significant (p-value=0.001). The mean IgG in the case group was 26.53 and in the control group was 48.69 which statistically significant (P=0.001). After the adjustment of the IgA and IgG levels on the variables such as age, gender, smoking, and history of autoimmune disease, there was a significant difference between the two groups (P-value=0.001) and in the control group, the IgA level was 11.42 and IgG levels were 21.2 points higher than the control group.Conclusion: Generally. The results of this study showed that serum IgA and IgG antibodies in the control group were more than in the case group and there was a negative correlation between Helicobacter pylori infection and MS, and according to previous studies, the results of this study suggest that Helicobacter pylori infection has a protective role in the pathogenesis of MS.Â
Authors and Affiliations
Seyed-Amirabbas Ahadiat,Seyed-Ali Masoud,Mohammad sadegh khorshidi,Zeinab Hosseinian,Alireza Namvari,
Keywords
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- EP ID EP709691
- DOI 10.52547/NL.1.1.28
- Views 74
- Downloads 0
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Helicobacter Pylori specific antibodies among multiple sclerosis patients
Background:Â Multiple sclerosis (MS) is one of the most common neurological diseases that occurs predominantly in young adults and more commonly in women. MS is a chronic inflammatory disease characterized by demyelinati...