Heliox delivered by high flow nasal cannula improves oxygenation in infants with respiratory syncytial virus acute bronchiolitis
Journal Title: Jornal de Pediatria - Year 2018, Vol 94, Issue 1
Abstract
Objective The objective of this study is to evaluate the hypothesis that use of heliox would result in improvement of gas exchange when used with high flow nasal cannula in infants with RSV acute bronchiolitis. Methods All patients that met the inclusion criteria were randomized to either heliox (70:30) or air–oxygen mixture 30% via high flow nasal cannula at 8L/min for a continuous 24h. Measurements were taken at baseline, after 2h, and at the end of the 24h. Results This prospective study included 48 patients. After 2h of treatment with heliox, the oxygen saturation and PaO2 significantly improved when compared with the air–oxygen group, 98.3% vs. 92.9%, 62.0mmHg vs. 43.6mmHg (p=0.04 and 0.01), respectively. Furthermore, PaO2/FiO2 ratio was significantly higher in the heliox group when compared with the air–oxygen group, 206.7 vs. 145.3. Nevertheless, CO2 showed better elimination when heliox was used, without significance. MWCA score dropped significantly in the heliox group, 2.2 points vs. 4.0 points in air–oxygen (p=0.04), 2h after starting the therapy. Conclusion Transient improvement of oxygenation in infants with RSV acute bronchiolitis during the initial phase of the therapy is associated with heliox when provided with HFNC, may provide a precious time for other therapeutic agents to work or for the disease to resolve naturally, avoiding other aggressive interventions.
Authors and Affiliations
Wael Seliem
Keywords
Related Articles
- EP ID EP482192
- DOI 10.1016/j.jped.2017.04.004
- Views 90
- Downloads 0
Physical fitness and activity, metabolic profile, adipokines and endothelial function in children
Objectives The prevalence of obesity is increasing. The aim of this study was to investigate if there is endothelial dysfunction in children with normal or excess weight, and whether the metabolic profile, adipokines, an...
Language and reading development in the brain today: neuromarkers and the case for prediction
Objectives The goal of this article is to provide an account of language development in the brain using the new information about brain function gleaned from cognitive neuroscience. This account goes beyond describing th...
Health-related physical fitness and weight status in 13- to 15-year-old Latino adolescents. A pooled analysis
Objective The aim of this study was to investigate the relation between health-related physical fitness and weight status in 13- to 15-year-old Latino adolescents. Method The final sample consisted of 73,561 adolescents...
Quality of human milk expressed in a human milk bank and at home
Objective To evaluate the quality of the human milk expressed at home and at a human milk bank. Methods This a retrospective, analytical, and observational study, performed by assessing titratable acidity records and th...
Role of serum (1,3)-β-d-glucan assay in early diagnosis of invasive fungal infections in a neonatal intensive care unit
Objectives To study the microbiological pattern of late onset neonatal sepsis cultures and to assess the diagnostic performance of serum (1,3)-β-d-glucan level for early diagnosis of invasive fungemia in high-risk infant...