Hemoglobin Patterns in Sickle Cell Hemoglobinopathies- A Large Prospective Study in North Maharashtra
Journal Title: MVP Journal of Medical Sciences - Year 2017, Vol 4, Issue 1
Abstract
Introduction: Sickle cell haemoglobinopathy is an inherited hemoglobinopathy resulting from a mutation occurring in betaglobin gene, on chromosome 11. The gene is prevalent in some tribes of North Maharashtra. The main aim of the study is to determine haemoglobin patterns in cases with sickle cell hemoglobinoathies in North Maharashtra using HPLC testing system. Material and Methods: This is a prospective study done over a period of 6 years. 10081 patients having positive solubility test or negative solubility test but having clinical suspicion of Sickle cell hemoglobinopathies were studied in detail and all samples were subjected for HPLC testing. Results: Prevalence of sickle cell hemoglobinopathy in this study was 70.36%. Most common pattern of haemoglobin observed was SA (89.72%). A slight female preponderance (54%) was noted. Predominant age group was paediatric (39.96%), followed by12-20yrs (33.97%). Oldest case for HbSS was 55yrs male. Predominant category affected was ST (82.05%). Conclusion: A very high prevalence of Sickle cell hemoglobinopathy was noted in this study. This is because the study was done in areas where Pawara and Bhill community resides who have a high frequency of HbS gene. Solubility test was found to be cost effective and easy screening test (Sensitivity being70.36%). HPLC found to be Rapid and accurate test for diagnosis of hemoglobinopathy and had helped in diagnosis of some rare heterozygous disorders like SA-HBQ India, SA-Hereditary persistence of foetal haemoglobin, HBD-SA. This is one of the largest and first of its kind prospective study which will help in prevention and cost effective management in targeted population.
Authors and Affiliations
Manjusha Punjaji Tambse, Maya Suresh Vasaikar, Sunil Santaram Chavan
Keywords
Related Articles
- EP ID EP430750
- DOI 10.18311/mvpjms/2017/v4i1/11831
- Views 132
- Downloads 0
Slowing of Alpha Waves on EEG, an Early Marker of Minimal Hepatic Encephalopathy
Introduction: Minimal Hepatic Encephalopathy (MHE) is the mildest form of spectrum of Hepatic Encephalopathy (HE) which remains undiagnosed due to lack of awareness. MHE has a negative effect on patient’s daily functioni...
To Study of the Effect of Melatonin on Noradrenaline Mediated Behavioural Responses after Electroconvulsive Shock (ECS) Administration
Objectives: To look for possible data regarding the effects of melatonin on noradrenaline mediated behavioral responses after Electroconvulsive Shock (ECS) administration in rats. Methods: Forty rats were divided in four...
A Case Control Study of Metabolic Syndrome in Psoriasis Vulgaris Patients at Tertiary Care Institute
Background: Psoriasis is a chronic, disfiguring, inflammatory and proliferative condition of skin influenced by both genetic and environmental factors. The prevalence of psoriasis vary from 0.1% to 3% in different popula...
Sputum Characteristics among “Chillum” Smoking ‘Sadhus’ of Kumbh Mela
A chillum consist a mixture of Cannabis and tobacco.Cannabis, also known as marijuana; it is a psychoactive drug from the Cannabis plant intended for medical or recreational use; nowadays widely being abused for getting...
Study of Aerosol Therapy Compliance in Bronchial Asthmatics
Asthma is commonly controllable but often neglected disease associated with huge burden to family and society. It is important to obtain optimal control to improve quality of life in asthmatics. The suboptimal control of...