Hemostasis: A Cell Based Model
Journal Title: Journal of Physiology and Pharmacology Advances - Year 2015, Vol 5, Issue 5
Abstract
For centuries homeostasis have been explained on the basis of the coagulation cascade where two separate pathways converge on a common pathway leading to the formation of thrombin. Thrombin in turn converts fibrinogen to fibrin. Monitoring of homeostasis is done based on this cascade model but certain discrepancies exist between the laboratory finding and the clinical findings. Hence a new cell based model of coagulation was designed which could provide reliable explanations to the pitfalls noted in the cascade model. Tissue factor bearing cell and platelets are mainly involved in the coagulation process based on cell based model. This new concept of coagulation is already accepted in the clinical settings. Hence it is high time that this model be included in the standard physiology textbooks where still the cascade model is described in detail.
Authors and Affiliations
B. Bahuleyan
Keywords
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