Hepatic Changes Induced by Leflunomide in Swiss Albino Mice Fetuses
Journal Title: International Journal of Contemporary Medical Research - Year 2017, Vol 4, Issue 6
Abstract
Introduction: Rheumatoid arthritis is an autoimmune disorder commonly affecting the females and pregnancy with this is a challenge for gynaecologists. Drugs used for treating rheumatoid arthritis during pregnancy should have its detailed teratological influences on the developing foetuses. The present study was carried out with the aim to know its teratogenicity specially on hepatic cells of mice foetuses. Material and Methods: The present teratological study was conducted in the Teratology laboratory of the Department of Anatomy, Institute of Medical Sciences, Banaras Hindu University, Varanasi. Results: Examined multiple slides of treated group fetuses and observed various histological changes. The consistent findings were dilated central vein, hepatocytes showing enlargement, cell division and nuclear degeneration kupffer cells were also increased in number. Conclusion: when given as 50mg/kg in single dose, It is producing microscopic changes in liver and at 15mg/kg as a continuous dosing it is embryolethal producing resorptions. Changes in liver architecture is more pronounced in early phases of gestation.
Authors and Affiliations
Krishna Pandey, Badal Singh, C Mohanty, SN Shamal, Nishtha Singh
Keywords
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