HEPATIC PRENEOPLASIA INDUCED BY N-NITROSODIMETHYLAMINE AND N-NITROSODIETHYLAMINE IN JAPANESE QUAIL EMBRYOS
Journal Title: TRADITION AND MODERNITY IN VETERINARY MEDICINE - Year 2016, Vol 1, Issue 1
Abstract
Toxic and carcinogenic effects induced in ovo by N-nitrosodimethylamine and N-nitrosodiethylamine in Japanese quail embryos were studied by histopathological methods. The obtained results indicate that both compounds induce preneoplastic hepatic alterations. The spectrum of macroscopic and microscopic lesions identified in carcinogen-treated embryos has been presented. The significance of avian embryos as an inexpensive and reliable model system for studies on hepatocarcinogenesis has been briefly discussed.
Authors and Affiliations
Branimir Nikolov, Ani Georgieva, Roman Pepovich, Kalin Hristov, Tandzhu Mehmedov, Vasil Manov, Elena Nikolova, Reneta Petrova, Ivelin Vladov, Anton Kril
Keywords
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