Hepatitis B Vaccine Response in Selected Immunocompromised Population
Journal Title: Journal of Medical Science And clinical Research - Year 2017, Vol 5, Issue 6
Abstract
Background: Prevention of hepatitis B is highly essential insusceptible population including immunocompromised individuals like patients with leukemia on chemotherapy and CKD patients on hemodialysis. Immune response is generally lower among these individuals. However, if protective antibody levels are attained, it confers protection on subsequent exposures to HBV. Aim: To evaluate the immune response to hepatitis B vaccine in immunocompromised. Methods: A cross sectional study conducted on 100 patients at a tertiary care center in northern Kerala for a period of 1 year. The study population divided into category I- Children with leukemia on chemotherapy and category II- CKD patients on hemodialysis, immunized within past 10 years were tested for anti-HBs by quantitative ELISA. Those who had inadequate response were tested for HBsAg and additional doses administered. Results: 76%showed adequate anti-HBs levels (Category I- 70% and category II- 82%). 7 subjects detected to be HBsAg positive were children with leukemia not immunized routinely but at the time of chemotherapy. In category I, 87.5% response was detected in those immunized as part of routine primary immunization and 53.8% in those immunized at the time of chemotherapy (p =0.009). In category II, 81.3% response seen with 0-1-2-6 regimen and 100% with 0-1-2-12(p =0.499).On giving additional doses the remaining subjects also responded. Conclusion: Protective immune response was achieved in all subjects after additional doses in indicated individuals. Immunization during chemotherapy was seen to be less effective in children with leukemia. This study emphasizes the importance of routine primary immunization.
Authors and Affiliations
Dr Nasha Kollathodi
Keywords
Related Articles
- EP ID EP522360
- DOI -
- Views 76
- Downloads 0
Clinico Epidemiological Profile of Children- With Hemophilia in South Kerala
Objective: to document the clinic epidemiological profile of children with hemophilia in south Kerala. Methods: observational prospective follow up study.60 simultaneous children who attended SAT hemophilia clinic were i...
A Study of Severity and Frequency of Anemia in Different Age Group in 6 Months to 5 years Children at a Teaching Hospital in Rural Haryana, India
Background: Anemia is a global health problem in children specially in under five children causing morbidity and mortality. Our aim of this study was to find the prevalence of anemia in different age group and its patter...
A Comparative Study of Lung Function Tests in Pregnant and Non-Pregnant Individuals
Introduction: Pregnancy isassociated with physiological changes in control of breathing and lung volumes. Aim: The aim of the present study was to describe the pulmonary function tests changes in pregnant and non-pregnan...
Role of Adenosine Deaminase and Insulin in Type 2 Diabetes Mellitus in Eastern India
Background & Objectives: Adenosine plays a crucial role in bioactivity of insulin and regulates insulin activity in type 2 diabetes mellitus (T2DM). The aim of our study was to study the altered levels of adenosine deami...
Hashimoto Thyroiditis-Association with Eosinophilic Infiltration in FNAC
Objective: To assess whether an eosinophilic infiltration of the thyroid gland has a higher association with diffuse thyroid swellings especially Hashimoto's thyroiditis and search for more cytological clues to increase...