Hepatitis C virus Infection in Nephrology Patients
Journal Title: Нирки - Year 2013, Vol 1, Issue 3
Abstract
Hepatitis C virus (HCV) infection leads to chronic liver disease, but also to extra-hepatic manifestations [1]. These include mixed cryoglobulinemia, lymphoproliferative disorders, and renal disease. HCV infection has been reported in association with distinct histological patterns of glomerulonephritis in native kidneys [2]. Membranoproliferative glomerulonephritis (MPGN) associated with type II cryoglobulinemia is the predominant type of HCV-related glomerulonephritis [3]. Less common glomerulonephritis diseases have also been reported in HCV-infected patients: these include MPGN without cryoglobulinemia [4], membranous glomerulonephritis (MGN) [4], focal segmental glomerular sclerosis [5–7], proliferative glomerulonephritis [4, 8, 9], and fibrillary [10, 11] and immunotactoid glomerulopathies [11]. Other anecdotal case reports have been also published: HCV-related IgA nephropathy [12], rapidly progressive glomerulonephritis [13], and thrombotic microangiopathy associated with cryoglobulinemic MPGN [14]. However, whether a causative effect between these glomerular diseases and HCV infection exists is still unknown.
Authors and Affiliations
Lionel Rostaing
Keywords
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