Hepatitis E: unresolved issues and research challenges
Journal Title: Postępy Nauk Medycznych - Year 2010, Vol 23, Issue 1
Abstract
This review presents the history of discovery of hepatitis E virus (HEV), global epidemiology, clinical course of hepatitis E in humans and results of experimental studies.Identification in 1983 HEV defined several epidemics of acute viral hepatitis of unknown etiology occurred in southeast and central Asia, India and Africa. Recently, sporadic cases of hepatitis E were confirmed in Europe and also in USA.Epidemiology and pathogenesis of hepatitis E is not very well known. The article presents results of clinical and basic studies on HEV and discuss the most interesting and still unsolved issues as: a) high mortality from HEV among pregnant women, b) the role of swine HEV in human, c) HEV source in immunocompromised individuals, and d) the casual relationship between HEV infection and liver pathology. Further study should be directed also to explain a relatively high frequency of anti-HEV antibody among healthy people in developed countries.Finally, the efficacy and perspectives of newly developed HEV vaccine are presented.
Authors and Affiliations
Krzysztof Krawczyński
Keywords
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