PARK2 polymorphisms predict disease progression in patients infected with hepatitis C virus

Background. The protein encoded by PARK2 gene is a component of the ubiquitin-proteasome system that mediates targeting of proteins for the degradation pathway. Genetic variations at PARK2 gene were linked to various di...

Challenges in treating liver fibrosis

Hepatitis C viral kinetics in Latino patients: a comparison to African American and Caucasian patients

Introduction. Response to hepatitis C treatment is known to differ by race; and, limited data suggests by ethnicity as well. A lower efficacy of HCV therapy in Latinos has been observed; whether higher doses may improve...

De-novo cholangiocarcinoma in native common bile duct remnant following OLT for primary sclerosing cholangitis

Primary sclerosing cholangitis (PSC) is a chronic, progressive, inflammatory and obstructive disease of the intra- and extra-hepatic bile ducts of unknown etiology. Currently, orthotopic liver transplantation (OLT) is th...

Effect of cirrhosis at baseline on the outcome of type 1 autoimmune hepatitis

Material and methods. With the aim of analyzing the influence of presence of cirrhosis at baseline on the outcome, we revised the evolution of a cohort of patients with type 1 autoimmune hepatitis, prospectively followed...