Hepatocellular Carcinoma with Bile Duct Tumor Thrombi (Icteric Hepatoma)– A 19 Year Experience from a Tertiary Care Centre
Journal Title: Journal of Medical Science And clinical Research - Year 2017, Vol 5, Issue 12
Abstract
Introduction/Objective: Hepatocellular carcinoma presenting with obstructive jaundice due to bile duct tumor thrombi is a rare entity, with a reported incidence worldwide of about 1 to 12 %. The objective of this study is to analyse the clinicopathological and post-surgical outcomes in patients who had hepatocellular carcinoma with bile duct tumor thrombi. Materials and Methods: 42 cases of pathologically proven Hepatocellular carcinoma with bile duct tumor thrombi in non-cirrhotic liver, who underwent hepatectomies at Institute of Surgical Gastroenterology and Liver Transplant, Government Stanley Medical College and hospital, between January 1997 and September 2016 were analysed retrospectively. Clinicopathological, biochemical, radiological, operative variables and post-operative morbidity and mortality were analysed. Results: Pre-operative AFP were elevated in 28 patients (> 400 ng/ml). Right hepatectomy with thrombectomy and T tube drainage, extended right hepatectomy with bile duct excision, left hepatectomy, extended left hepatectomy with bile duct excision, left lateral segmentectomy were done in 17,11,10,2 and 2 patients respectively. 14 patients had significant post-operative morbidity while mortality was seen in three patients. Median survival was about 27.2 months. Tumor recurrence was observed in 28 of 42 cases (66.67%) with a median time to recurrence of about 10.3 months. Conclusion: Bile duct tumor thrombi does not preclude hepatic resection and these patients who are otherwise fit to undergo hepatectomy are offered surgery as the first line treatment.
Authors and Affiliations
Dr R. Kamalakannan
Keywords
Related Articles
- EP ID EP519937
- DOI -
- Views 49
- Downloads 0
Carcinoma Cervix with Cutaneous Metastasis: A Case Report
Cutaneous metastasis is an uncommon entity in gynecologic cancer. Though carcinoma cervix is the commonest female malignancy in the developing countries, cutaneous involvement of cervical cancer is particularly unusual,...
Large Stone in Oesophagus in a Two Month Old Premature Infant
We report a rare case of large stone in esophagus of a 2 month old premature male causing obstructive and respiratory symptoms. Although foreign body oesophagus is not uncommon, however unusual age and circumstances invo...
Standard Anterior Repair of Hiatus Hernia During Laparoscopic Sleeve Gastrectomy Causes a Significant Reduction in Symptoms of GERD
Bariatric surgery is the most effective treatment for gastro-esophageal reflux disease (GERD) in obese patients. Published data reporting the results of laparoscopic sleeve gastrectomy (LSG) and hiatus hernia repair in p...
Serum Profile of Selected Oxidants and Antioxidants in Patients of Rheumatoid Arthritis
The level of selected markers of oxidative stress (protein carbonyls, nitrite, malondialdehyde) and antioxidants (ceruloplasmin and ascorbic acid) were measured in the serum of 40 patients with rheumatoid arthritis. 20 h...
Plasmodium vivax Detected on Anophles punctulatus Using ELISA: A Vector Confirmation Study in Tamraw District, A Remote Area With High Incidence of Malaria, West Papua Province-Indonesia
Background: Tamraw District is a new administrative district of West Papua Province with high incidence rate of malaria. The aim of the study was to detect Plasmodiumsp in Anophelessp using ELISA assay in Tamraw District...