Hepatoprotective Activities of Girang Leaf Ethanol Extracts (Leea angulata Korth. Ex Miq) on Wistar Rats Induced by Paracetamol
Journal Title: IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS) - Year 2019, Vol 14, Issue 1
Abstract
Paracetamol is an analgesic and antipyretic drug that has a toxic effect when it is used with excessive doses. The toxicity of paracetamol is caused by the formation of NAPQI reactive metabolites and paracetamol inducing the formation of free radicals which can cause liver cell damage. This study aims to test the hepatoprotective activity of ethanol extract of girang leaves (Leea angulata Korth. Ex Miq) in male white rats of the Wistar strain.Acute liver damage was done by inducing paracetamol at a dose of 750 mg / kg BW. Ethanol extract of girang leaves was given at a dose of 50, 100, 200, and 400 mg/kg per oral for 14 days. Liver biochemical parameters (ALT activity) of rat serum were measured by using a spectrophotometer. The results showed that the mean ALT activity of rat given girang leaves ethanol extract of 50 mg/kg BW (82.30 ± 12.06) U/L, 100 mg/kg BW (71.70 ± 2.86) U/L, 200 mg/kg BW (43.50 ± 1.56) U/L, and 400 mg/kg BW (42.90 ± 1.86) U/L significantly (p˂0.05) lower than the mean of rat of ALT activity which was only induced by paracetamol (109.90 ± 12.06) U/L. The conclusion of this study is that ethanol extract of girang leaves has hepatoprotective activity by reducing the ALT activity of rats given excessive paracetamol with an effective dose of 200 mg/kg BW.
Authors and Affiliations
Ni Luh Rustini, Ida Bagus Putra Manuaba, Bagus Komang satriyasa
Keywords
Related Articles
- EP ID EP431599
- DOI 10.9790/3008-1401010105.
- Views 46
- Downloads 0
Checklist of plants in the University Botanic Garden of Maseno and their significances to the society
t:A botanical garden is an area set aside and maintained by an organization for growing and studying various groups of plants for aesthetic, conservation, economic, educational, recreational and scientific purposes. A lo...
Synthesis, Characterization and Biological Evaluation of Some Benzothiazole Derivatives as Potential Antimicrobial Agent.
A new series of benzylidine-2-imino-6-nitro-1,3- benzothiazole , benzylidine-2-imino-6-methoxy-1,3- benzothiazole and benzylidine-2-imino-6-methyl-1,3- benzothiazole was synthesised by condensation with different aromati...
Testosterone Concentration and Testicular Histomorphology of Rats Exposed to Hippocratea Africana Root Bark Extract
Malaria is a scourge of the tropical region of the world, affecting mostly the poor who cannot afford the World Health Organisation (WHO) recommended artemisinin combination therapy. This results in the continuous relian...
Effect of Aloe vera gel on lipid profile and some serum biomarkers of liver function in high salt fed Wistar rats
This study examined the effect of Aloe vera gel on lipid profile and some serum biomarkers of liver function in high salt-fed wistar rats. Twenty male wistar rats (200-250g) were randomly assigned into four groups (n=5):...
Prostacyclin and Interaction with Diacylglycerol Lipase and CDP Diacylglycerol; Possibility of De Novo Synthesisof Prostacyclin or Related Congeners by Novel Mechanisms
Prostacyclin is a strong cardioprotective hormone released by the endothelium of the blood vessels. Prostacyclin is present in equilibrium with several vasoactive agents in cardiovascular system. In recent years, prostac...