Hepatoprotective Activity of Holostemma ada Kodien shcult, Extract against Paracetamol Induced Hepatic Damage in Rats
Journal Title: European Journal of Medicinal Plants - Year 2015, Vol 6, Issue 1
Abstract
Aim: To study the hepatoprotective activity of alcoholic extract of Holostemma ada Kodien Shcult against paracetamol (PCM) induced liver damage in rats. Place and Duration of Study: Department of pharmaceutical chemistry and department of pharmacology Geethanjali College of Pharmacy, Cherryal, Keesara, Ranga Reddy District, Andhra Pradesh, India during June 2012 and Jan 2014. Methods: Hepatotoxicity was induced by paracetamol (PCM) and various biochemical parameters were assessed to confirm the induced degrees of hepatoprotoxicity. The various extracts were tested on animals and various biochemical parameters such as serum aspartate amino transferase (AST), alanine amino transferase (ALT), alkaline phosphatase (ALP) and total serum bilirubin (SB) were investigated the hepatoprotective activity was also confirmed by histopathological studies of normal and hepatodamage and post treatment studies with the extract. The Results: Pre-treatment of the rats with alcoholic extract prior to paracetamol (PCM) administration caused a significant reduction in the values of AST, ALT, ALP and SB (p<0.01) approximately comparable to the hepatoprotective of standard drug was silymarin and confirmed by histopathological examination of the liver tissue of control and treated animals. Conclusion: From the results it can be concluded that Holostemma ada Kodien Shcult possesses the hepatoprotective effect against paracetamol (PCM) induced liver damage in rats.
Authors and Affiliations
Junapudi Sunil, Janapati Yasodha Krishna, Pallaval Veera Bramhachari
Keywords
Related Articles
- EP ID EP350256
- DOI 10.9734/EJMP/2015/12117
- Views 123
- Downloads 0
Study of Cytotoxic, Thrombolytic and Anthelmintic Activity of Extract of Neolamarckia cadamba (Roxb.) Leave
Aim of the Study: The study was aimed to evaluate the cytotoxic, thrombolytic and anthelmintic activity of methanolic extract of the stem of Neolamarckia cadamba (Roxb.). Place and Duration of Study: The research was ca...
Antimicrobial, Antioxidant and Protective Effect of Methanol Extract of Trichilia emetica (Meliaceae) Stem and Root Bark against Free Radical-induced Oxidative Haemolysis
Background: The objectives of this study are to investigate the antimicrobial, antioxidant and antiradical properties of methanol extract of the stem and root bark of Trichilia emetica on a model of free radical-induced...
Hepatoprotective Effect of Origanum elongatum against Carbon Tetrachloride (CCl4) Induced Toxicity in Rats
Aims: This study was undertaken to investigate the potential effect of methanol extract of Origanum elongatum (OEME) given orally by gavage against intraperitoneal injection a single dose of Carbon tetrachloride (CCl4)(0...
Antifungal and Cytotoxicity Activity of Plants Used as Herbal Teas in Tanzania
Aim: The current study was designed to determine antifungal and cytotoxicity activity of Rhus vulgaris, Sphaeranthus bullatus, Osyris lanceolata, Ocimum gratissimum, Cymbopogon citratus, Acacia nilotica and Ty...
Chemical Composition and Ovicidal, Larvicidal and Pupicidal Activity of Ocimum basilicum Essential Oil against Anopheles gambiae. (Diptera: Culicidae)
Background: Malaria remains a serious Public Health issue in the sub-Saharan regions. Although Anopheles gambiae (main malaria vector) has developed resistance against commonly used insecticides, the emergence of this re...