Hepatoprotective Activity of Holostemma ada Kodien shcult, Extract against Paracetamol Induced Hepatic Damage in Rats
Journal Title: European Journal of Medicinal Plants - Year 2015, Vol 6, Issue 1
Abstract
Aim: To study the hepatoprotective activity of alcoholic extract of Holostemma ada Kodien Shcult against paracetamol (PCM) induced liver damage in rats. Place and Duration of Study: Department of pharmaceutical chemistry and department of pharmacology Geethanjali College of Pharmacy, Cherryal, Keesara, Ranga Reddy District, Andhra Pradesh, India during June 2012 and Jan 2014. Methods: Hepatotoxicity was induced by paracetamol (PCM) and various biochemical parameters were assessed to confirm the induced degrees of hepatoprotoxicity. The various extracts were tested on animals and various biochemical parameters such as serum aspartate amino transferase (AST), alanine amino transferase (ALT), alkaline phosphatase (ALP) and total serum bilirubin (SB) were investigated the hepatoprotective activity was also confirmed by histopathological studies of normal and hepatodamage and post treatment studies with the extract. The Results: Pre-treatment of the rats with alcoholic extract prior to paracetamol (PCM) administration caused a significant reduction in the values of AST, ALT, ALP and SB (p<0.01) approximately comparable to the hepatoprotective of standard drug was silymarin and confirmed by histopathological examination of the liver tissue of control and treated animals. Conclusion: From the results it can be concluded that Holostemma ada Kodien Shcult possesses the hepatoprotective effect against paracetamol (PCM) induced liver damage in rats.
Authors and Affiliations
Junapudi Sunil, Janapati Yasodha Krishna, Pallaval Veera Bramhachari
Keywords
Related Articles
- EP ID EP350256
- DOI 10.9734/EJMP/2015/12117
- Views 128
- Downloads 0
Microbiological Contamination and Anti-bacterial Traits of Common Oral Herbal Medicinal Products within Dhaka Metropolis
Aims: Present study endeavored to examine the growth and survival of microorganisms within 6 categories of oral herbal medicines commonly used by the community within Dhaka metropolis. Methodology: Samples were analyzed...
Immunological and Haematological Disturbances in Diabetes Mellitus: Modulatory Role of Diets Containing Vernonia amygdalina Leaves
Aim: The aim of this study was to determine some makers of immunology and haematology in Streptozotocin -induced diabetic wistar rats consuming Vernonia amygdalina leaf diets in order to evaluate the involvement of the d...
Toxicity and Pharmacognostic Standards for Laxative Properties of Nigerian Cassia sieberiana and Senna obtusifolia Roots
Aims: Research for sourcing laxative crude drugs among Nigerian Cassia/Senna species has continued. The roots of Cassia sieberiana and Senna obtusifolia, reported as mild laxatives, were subjected to pharmacognostic and...
Hepatoprotective Effects of Rubus idaeus L. Leaves against CCl4-Induced Liver Injury via Antioxidant, Anti-inflammatory and Antiapoptotic Mechanisms
Aims: To investigate the hepatoprotective effects of red raspberry (Rubus idaeus L.) leaves against oxidative stress, inflammation and apoptosis induced by carbon tetrachloride (CCl4) in rats. Study Design and Methodolog...
Cytotoxicity of the Aqueous Extract of Clerodendrum splendens on HaCaT Keratinocytes
Clerodendrum splendens G. Don (Family Verbenaceae) has been used for centuries to treat various medicinal problems in Africa, including the treatment of wounds and other skin conditions. Though several studies have been...