HEPATOPROTECTIVE AND ANTIOXIDANT ACTIVITY OF ALPINIA MALACCENSIS ROSCOE RHIZOME
Journal Title: International Journal of Pharmacy and Pharmaceutical Sciences - Year 2015, Vol 7, Issue 2
Abstract
Objective: The present study aims to evaluate hepatoprotective activity, antioxidant activity and total phenolic content of methanolic extract from rhizomes of A. malaccensis.Methods: The hepatoprotective activity in mice was studied by inducing oral dose at 250 mg/kg and 500 mg/kg b. wt., antioxidant activity was evaluated by different method viz; the superoxide anion scavenging activity, hydroxyl radical scavenging activity, nitric oxide scavenging activity, DPPH radical scavenging activity and total phenolic content.Results: The mice were significantly re established from hepatotoxicity evident by analyzing the factors such as triglycerides, ALT, AST, glucose, cholesterol, total protein, bilirubin, albumin and urea levels. Further more histopathological results revealed the significant improvement of liver. Methanolic extracts of rhizomes of A. malaccensis showed abilities to scavenge hydroxyl, superoxide free radicals, nitric oxide, DPPH with IC50 values of 50.42, 71.19, 96.38, 61.46 µg/ml and reducing power ability with the RP50 value of 183.54 µg/ml. The methanolic extract was found to have a total phenolic content of 48.18 µg/ml.Conclusion: Our study reveals the therapeutic effect of A. malaccensis on treated mice as well as the strong antioxidant potential with its total phenolic content. A. malaccensis so may be used as herbal medicine to replace synthetic one.Â
Authors and Affiliations
Sonali Sethi, Om Prakash, A. k. Pant, Munish Batra, Mahesh Kumar
Keywords
Related Articles
- EP ID EP579067
- DOI -
- Views 68
- Downloads 0
ANALYSIS OF THREE CARDIOVASCULAR DRUGS IN THEIR TERNARY MIXTURE USING GREEN ANALYTICAL METHODOLOGY OF SMART SPECTROPHOTOMETRIC METHODS AND RP-HPLC METHOD
Objective: Development and validation of two new, simple and specific analytical techniques for the simultaneous determination of a ternary mixture of co-administered cardiovascular drugs ticagrelor (TICA), irbesartan (I...
A CASE OF HYPOTHYROIDISM INDUCED RECURRENT DEPRESSIVE DISORDER
Recurrent depressive disorder is a lifelong illness with relapses and remissions. The aetiology is biopsychosocial, genetic factors contributing and life stressors exaggerating the disease. Due to recurrent episodes the...
EFFECT OF NARINGENIN ON LIPIDS, LIPOPROTEINS AND LIPID METABOLISING ENZYMES IN 7,12-DIMETHYL BENZ(A)ANTHRACENE-INDUCED MAMMARY CARCINOGENESIS IN SD RATS
Objective: Mammary carcinoma is one of the most common and prominent cause of cancer-related death in women worldwide. The role of fatty acid synthesis and altered lipid metabolism in cancer progression was well establis...
NEURO-PROTECTIVE EFFECTS OF GINKGO BILOBA LEAVES EXTRACT ON CEREBRAL ISCHEMIA-REPERFUSION INJURY INDUCED EXPERIMENTALLY IN OVARIECTOMIZED RATS
Objective: This study investigated the possible neuroprotective effects of Ginkgo biloba on cerebral ischemia-reperfusion (I/R) injury in ovariectomized rats.Methods: Rats were randomly allocated into 5 groups as follows...
ANTIFUNGAL ACTIVITY OF CHLOROFORM AND ACETONE EXTRACTS OF SOLANUM DOLICHOSEPALUM AGAINST FUSARIUM OXYSPORUM
Objective: Evaluate the effectiveness of acetone (A) and chloroform (C) extracts of the plant Solanum dolichosepalum to control two isolated strains (S1 and S2), each from different specimen passiflora of the fungus Fusa...