Hepatoprotective Effect of Crocus sativus on Amiodarone-Induced Liver Toxicity
Journal Title: Journal of Pharmaceutical Research International - Year 2016, Vol 12, Issue 4
Abstract
Aims: The purpose of this study was to investigate the hepatoprotective effect of aqueous and ethanolic extract of Crocus sativus in amiodarone-induced hepatotoxicity in rabbits. Methods: Study was divided into 2 major groups; acute group and prophylactic group and randomized control trial was used. Acute group was further divided into five sub groups (n=5) i.e. control group (group I), amiodarone group (group II), saffron group (group III), amiodarone + aqueous saffron group (group IV), and amiodarone + ethanolic saffron group (group V). Hepatotoxicity was induced by intraperitoneal administration of 200 mg/kg amiodarone solution thrice a day in group II, IV and V. Aqueous extract of saffron (100 mg/kg) was administered intraperitoneally once a day in group III and group IV. Ethanolic extract of saffron (100 mg/kg) was given to group V. However saffron extracts were administered half hour before the amiodarone first dose in both the groups. Aqueous extract of saffron (100 mg/kg) was given to rabbits for seven days as prophylactic therapy and then 200 mg/kg amiodarone solution was injected thrice a day in order to observe the hepatoprotective effect of Crocus sativus. After the experimental period, blood samples were collected for the evaluation of biochemical parameters. Histopathological examination was performed also. Results: Study showed that both aqueous and ethanloic extract of Crocus sativus significantly decreased serum ALT and AST enzyme activities and significant results were obtained when compared to the amiodarone group. Conclusion: Based on the results it was concluded that addition of Crocus sativus to the treatment protocol of patients maintained on amiodarone for long time period can be recommended to prevent the liver injury.
Authors and Affiliations
Humayun Riaz, Noviara Saleem, Mobasher Ahmad, Yasir Mehmood, Syed Atif Raza, Sabahat Khan, Rukhsana Anwar, Sairah Hafeez Kamran
Keywords
Related Articles
- EP ID EP342219
- DOI 10.9734/BJPR/2016/27219
- Views 79
- Downloads 0
In vitro Antisalmonellal and Antioxidant Activities of the Crude Extracts and Fractions from the Stem Bark of Albizia gummifera (J. F. Gmel.) C. A. Sm.
Aims: Typhoid fever is an infectious disease, which continues to be a serious health problem and remains a major cause of morbidity and mortality in the developing country. Considering the ethnopharmacological relevance...
Free Radicals Scavenging and Protein Protective Property of Ocimum sanctum (L)
Ocimum sanctum (L) is a well-known herbal plant used for the treatment of bronchitis, malaria, diarrhea, dysentery, skin disease, arthritis, eye diseases and insect bites. It is proposed to have anticancer, antidiabetic,...
Proximate, Mineral and Anti-nutrient Contents in Psophocarpus tetragonolobus (L) DC. (Winged Bean) Leaves
The leaves of Psophocarpus tetragonolobus (L) DC. (Winged bean) was evaluated for the proximate, mineral and anti-nutritional composition. Atomic absorption spectrometry was used in determination of the leaves for Phosph...
Development and Validation of New Analytical Method for the Determination of Particle Size Distribution of Metformin Hydrochloride Using Laser Based Particle Size Analyzer
Metformin Hydrochloride has characteristic nature of lump formation and determination of particle size with reproducible result is difficult and particle size determination method is not reported in literature. Hence nov...
Tricyclic Pyrazoles: Synthesis, Characterization, Antimicrobial, Antituberculosis, and Antitumor Activity of N,1-Diphenyl-1,4-dihydrothiochro-meno[4,3-c]pyrazole-3-carboxamide-5,5-dioxide Derivatives
Aims: A series of N,1-diphenyl-1,4-dihydrothiochromeno[4,3-c]pyrazole-3-carboxamide 5,5-dioxide derivatives (6a-m) were synthesized and evaluated for anticancer, antibacterial, and antifungal activity. Methodology: React...