Hepatotoxicity of Ethanol Extract of Adenium obesum Stem Bark in Wistar Rats
Journal Title: Journal of Pharmaceutical Research International - Year 2014, Vol 4, Issue 9
Abstract
Aims: Adenium obesum is a known medicinal plant thereby creating the need for the evaluation of its toxicity and histopathological effects on the liver of female Wistar rats orally administered ethanol extract of the plant’s stem bark. Place and Duration of Study: Department of Veterinary Pathology, Ahmadu Bello University, Zaria, Nigeria, between January 2011 and January 2012. Methodology: Ethanol extraction of A. obesum stem bark was performed prior to screening it for its phytochemical constituents. Female rats per group were orally administered by gavage pre-defined doses (300mgkg-1, 2000mgkg-1 and 5000 mgkg-1) of the extract separatively in a stepwise procedure and observed for signs of toxicity. Control rats were administered distilled water placebo. Results: The extract contained some alkaloids, saponins, tannins, flavonoids, glycosides, steroids and triterpens with no anthraquinones. Exposed rats did not show signs of toxicity and neither was there any mortality. Changes in aspartate aminotransferase, alanine aminotransferase and alkaline phosphatase activities were non-significant (p>0.05). Congestion and fatty degenerative changes were seen in the liver of the exposed rats, which were not significantly (p>0.05) different in exposed rats compared to the control. Conclusion: Adenium obesum did not cause major hepatic damage in the exposed rats and therefore, it is a safe oral medicinal plant within the extract dose and exposure period used in the study.
Authors and Affiliations
Samson Eneojo Abalaka, Muhammad Yakasai Fatihu, Najume Doguwar Giginya Ibrahim, Suleiman Folorunsho Ambali
Keywords
Related Articles
- EP ID EP344879
- DOI 10.9734/BJPR/2014/7667
- Views 79
- Downloads 0
Correlation of Serum IL-17 with Level of Vitamin D and IgE in Asthmatic Patients
Background: Allergic asthma is a chronic inflammatory disorder of the airways caused by hypersensitivity and characterized by Th2 cytokine i.e. IL-4, that contribute to enhanced proliferation and differentiation of Th...
Medicinal Values of Trichosanthus cucumerina L. (Snake Gourd) - A Review
Snake gourd is an annual climber and it’s commonly called as snake gourd, viper gourd, snake tomato or long tomato. The fruit is usually consumed as a vegetable due to it is good nutritional value. The fruit is a good so...
Bioactive Chemical Constituent Analysis, in vitro Antioxidant and Antimicrobial Activity of Whole Plant Methanol Extracts of Ulva lactuca Linn
Aims: To analyse the bioactive chemical constituents and evaluate in vitro antioxidant and antimicrobial activities of whole plant methanol extracts of Ulva lactuca Linn. Study Design: Preliminary phytochemical screening...
In vitro- In vivo Correlation Studies of Modified Release Tolterodine Tablet Dosage form in Rabbits
Tolterodine is an antimuscarnic drug that is used for sympathetic treatment of urinary incontinence. Tolterodine modified release tablet, was investigated in rabbit for pharmacokinetic and in vitro–in vivo correlation st...
The Protective Effect of Calcitriol on Diabetic Neuropathy in STZ-induced Diabetic Rats
Diabetic peripheral neuropathy (DPN) is one of the diabetic complications that have a complex etiology and even with good glycemic control can have severe consequences. To date, there is no effective treatment for DPN. T...