HER2 Status in Male Breast Carcinoma: a Single North African Institution Experience of 10 Cases and Review of the Literature
Journal Title: Journal of Surgery and Surgical Research - Year 2015, Vol 1, Issue 3
Abstract
Background: To investigate clinic-pathological characteristics, hormonal receptors and HER2 receptor of male breast cancer. Materials and methods: Retrospective study of 10 cases between 2010 and 2013. The studied parameters were: tumor size, histological type, histological grade, lymph node status, hormonal status and overexpression of HER2. Results: The average age of our patients was 60.2 years, in 70% of cases; the histological size that was found was T4; and infiltrating ductal carcinoma was diagnosed in all cases. The grades classification was as follow: grade 2 (30%) and grade 3 (70%). 70% of cases had lymph node metastasis. Estrogen and progesterone receptors (ER,PR) were positive in 60% of tumors. Overexpression of HER2 was positive (Score3) in one case. Luminal B was the most common subtype in our study. Conclusion: Male breast cancer is a rare disease with a poor prognosis despite the recent increase in incidence in recent years. The diagnosis is often delayed and injuries are treated in advanced stages.
Authors and Affiliations
Mrabent Meriem N, Harir Noria, Sellam Feriel, Zeggai Soumia, Tou Abdenacer, Diaf Mustapha, Salah Rachida, Moulesshoul Soraya
Keywords
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- EP ID EP349976
- DOI 10.17352/2455-2968.000013
- Views 77
- Downloads 0
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