HER2/neu Expression in Colorectal Cancers
Journal Title: International Journal of Contemporary Medical Research - Year 2017, Vol 4, Issue 6
Abstract
Introduction: Colorectal carcinoma ranks third among the most common leading causes of cancer-related mortality in the world. Her2/neu oncogene one is of four epidermal growth factor receptors. Clinically, amplification and/or overexpression of Her2/neu has been associated with poor prognosis in a number of tumor types such as breast and ovarian cancer. Conflicting data exist about the prevalence of HER-2/neu overexpression in colorectal cancer ranging from 0 to 83%. This study was done to check the expression of Her-2/neu in colorectal cancers. Material and Methods: The study included 50 patients with a histological diagnosis of colorectal cancers at our department between 2014 January and June 2015. HER2/neu immunohistochemistry was done on this cases and scored similar to invasive breast carcinomas.IHCs were analysed with grades and stages of colon cancers. Results:The mean age in this study was 60.04 years. Male female ratio was 1:1. Sixty percentage tumours were from colon and all the cases were adenocarcinoma NOS. Eighty percentage of cases were grade 1 tumours and stage B was the common stage noticed. Thirtytwo percentage of cases showed lymph node metastasis. Only 24% of cases showed Her2/neu positivity and maximum positive cases were from grade1 tumours. Maximum number of Her2/neu positivity was given by stage B tumours. Conclusion: HER2/neu protein expression was observed in colorectal cancer but rarely in the therapeutic range (2+ and 3+).
Authors and Affiliations
Suma S, Shameem K Ummerali
Keywords
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