Herpes Simplex Virus type 2, Epstein Barr Virus and Human Papilloma Virus Co-infection in Cervical Squamous Cell Carcinoma among Sudanese Females
Journal Title: INTERNATIONAL JOURNAL OF CURRENT RESEARCH IN MEDICAL SCIENCES - Year 2018, Vol 4, Issue 2
Abstract
Introduction: Squamous cell carcinoma (SCC) of the uterine cervix is the second cancer among Sudanese females, peculiar tendency to present late due to lack of education and efficient screening programs. High risk HPV 16, 18 have been detected, also existence of HPV 35 was documented.There are postulations to incriminate other viruses in the etiology of cervical carcinoma like Epstein - Barr virus and herpes simplex virus the exact role of these viruses in the etiology of cervical cancer is not clear. The aim of this study was to clarify the existence and prevalence of these viruses among Sudanese women with cervical cancer, and verify the existence of new players in cervical cancer. Method: This was observational case control study conducted in Khartoum state-Sudan during period from October 2013 to June 2016. One hundred and eighty paraffin-embedded tissue blocks were included in this study; 98 blocks from patients with cervical squamous cell carcinoma (case group) versus 82 cervix tissue blocks malignancy-free (control group), were subjected to detection of HSV-2, EBV and HPV infections using Polymerase Chain Reaction (PCR) and Immunohistochemistry (IHC) techniques. Results: HPV infection was detected in 41.8% among cases, while the healthy individuals reported2.4% with high statistically significant different, the P value was 0.000 with 28.8 odds ratio (Ors 28.8; 95% CIs=6.686-123.86; P=0.000),ladies with HPV infection have 28.8 chance to develop cervicalcancer. HSV-2 revealed positivity in 6.1% of the cases biopsies, and in 1.2% of the controls biopsies,with no statistically significant correlation, the P value was 0.128. EBV was positive in 2% of the cancer samples, while the non cancer samples reported in 0.00%, with no statistically significant correlation, the P value was 0.501. Conclusion: HPV, HSV-2 and EBV infections were present in cervix SCC samples, but with different positive rates. HPV remains the major virus associated with cervix SCC tumorigenesis. Both HSV-2 and EBV their roles in the development of cervical SCC appear as bystanders rather than oncoviruses or cofactors. Further studies are needed to determine its precise role.
Authors and Affiliations
Mohammed Abdelgader ELSHEIKH 1*, Ibrahim Bakhit YOUSIF 2 , Mahmoud Ibrahim OSMAN 3 , Awad Eljeed Abugooda Alobaid 4 , Ahmed ABDELBADIE 5 , Elsadig Ahmed ADAM 6
Keywords
Related Articles
- EP ID EP552758
- DOI 10.22192/ijcrms.2018.04.02.016
- Views 113
- Downloads 0
Knowledge and attitude toward risk factors of cardiovascular disease in Iranian population: A systematic review
Introduction: According to the high prevalence of cardiovascular diseases (CVDs) in developing countries as well as high treatment expenses for patients and health-care systems, CVDs prevention in such societies has a gr...
Physical fitness profile of children with various locomotorsdisability in Ahmednagar district
We can conclude the study by saying that, while performing physical fitness test in disabled children the most affected component was 1 mile walk test, i.e. aerobic functioning and the least affected component was grip s...
A study of effect of special lecture on awareness related to organ donation among second year undergraduate medical students of a Medical College in a Metropolitan City, Maharashtra.
Objective : a) To understand the awareness about organ donation among the Undergraduate students. b) To find the effect of special lecture on the knowledge and practice of Undergraduate students related to organ donation...
EEG changes during acute alternate nostril breathing exercise in healthy adult male
Background and objectives: There are very few studies investigating the acute effects of alternate nostril breathing (ANB) on EEG. We aimed to investigate the changes in EEG before, during and immediately after alternate...
Snake Bites Problem in over the world
A snake bite is an injury caused by the bite of a snake, especially a venomous snake. A common symptom of a bite from a venomous snake is the presence of two puncture wounds from the animal's fangs. Sometimes venom injec...