Toxicity Studies of Poly Herbal Siddha Formulation Narasinga Rasayanam
Journal Title: INTERNATIONAL JOURNAL OF CURRENT RESEARCH IN MEDICAL SCIENCES - Year 2018, Vol 4, Issue 1
Abstract
Narasinga Rasayanam(NR) is a poly herbal traditional Siddha preparation. The name Narasingam denotes Serankottai (Semecarpus anacardium) based formulation which is widely used in South India as traditional Siddha medicine for the treatment of peptic ulcer (Gunmam) and for regenerative conditions. It is more popular medicine and also in use for very long period but there is no documented data on its safety. The present study is aimed to investigate the acute and sub acute toxicity profile of Narasinga Rasayanam(NR) in healthy Wistar rats by OECD guidelines. In acute toxicity study, NR (2000mg /kg) was administered to the wistar albino rats and observed for 14 days. For Sub acute toxicity study the drug NR was administered with the dose of 144 mgm, 720 mgm, 1440 mgm for 28 days. The results of this study showed that the drug NR neither produced significant changes in the consumption of food and intake of water, nor affected biochemical parameters, haematological parameters and there was no change in histopathology studies. Finally this study results concluded that, the drug NR at a dose of 2 g/kg was found to be safe as a potent Anti-Ulcer agent in Wistar rats.
Authors and Affiliations
S. Iyswarya1 , S. Visweswaran2 V. Banumathi3
Keywords
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- EP ID EP550423
- DOI 10.22192/ijcrms.2018.04.01.015
- Views 130
- Downloads 0
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