Hidradenitis suppurativa/Acne inversa – etiopathogenesis, clinical presentation and therapeutic options
Journal Title: Postępy Nauk Medycznych - Year 2012, Vol 25, Issue 10
Abstract
Hidradenitis suppurativa/acne inversa (HS) is a chronic recurrent inflammatory skin disease affecting mainly the intertriginous areas. Cutaneous nodules, abscesses, subsequent widespread deep inflammation, sinus tract and fistulas formation with foul-smelling purulent discharge are the main clinical features of the disease. Etiology of HS is believed multifactorial and not clear, but the cigarette smoking and obesity are the established triggering factors.<br>Pathogenesis is not well understood yet. The primary event is a follicular occlusion with secondary inflammation, infection and destruction of the pilosebaceous unit and extension of inflammation to the adjacent subcutis. Treatment depends upon the clinical stage of the disease. There are various therapeutic options known, including antibiotics, antiandrogens, retinoids, systemic corticosteroids, TNF inhibitors, inmmunosupresive/anti-inflammatory agents, all of them used with limited results. The most effective treatment is the radical wide excision of the affected area. Due to its chronicity, recurrent character and specific multifocal embarrassing location HS is physically, psychologically and socially disabling condition with considerable impairment of the quality of life.
Authors and Affiliations
Grażyna Chodorowska
Optimising antiplatelet therapy in acute coronary syndromes
Platelet mediated thrombosis plays central role in pathogenesis of acute coronary syndromes (ACS). The main receptors acting in this process: P2Y12 and GPIIb/IIIa, are major targets of pharmacotherapy. Inhibition of anot...
Współczesne poglądy na przewlekłą dysfunkcję przeszczepu nerki
Wyniki zarówno wczesne, jak i odległe, przeszczepiania nerek ulegają systematycznej poprawie. Tym niemniej, nadal około 5% chorych rocznie wraca do programu leczenia hemodializami z powodu utraty funkcji przeszczepionej...
Results of Leeds-Keio prosthesis application in the treatment of anterior knee instability
Knee injuries are among the most frequent sport injuries. Mostly several structures are affected at the same time. One of the most common is traumatic rupture of anterior cruciate ligament. As a result, anterior and rota...
The pancreatojejunostomy after pancreatoduodenectomy. The review of techniques including our own method of the anastomosis
Pancreaticoduodenectomy (PD) is the treatment of choice for resectable periampullary tumors. The most difficult, time-consuming, and complication-prone step in pancreaticoduodenectomy is the pancreaticojejunostomy step....
Diagnostic and treatment advances of adults acute lymphoblastic leukemia
Acute lymphoblastic leukemia (ALL) according the WHO 2008 classification is a type of precursor lymphoid neoplasms which is divided into leukemia/lymphoblastic lymphoma B type (75% ALL) and leukemia/lymphoblastic lymphom...