High-affinity IgE receptor gene polymorphism and allergic rhinitis in a Polish population
Journal Title: Otolaryngologia Polska - Year 2014, Vol 68, Issue 4
Abstract
Introduction: The high-affinity IgE receptor (FceRIb subunit int 2) gene polymorphism is a candidate gene in atopic diseases and is associated with atopy. The aim of this biochemical study was to investigate the association of its intronic mutation and allergic rhinitis in a Polish population. Materials and methods: 100 atopic patients and 85 controls were included in the study. Polymerase chain reaction-based analysis for FceRIb subunit int 2 gene polymorphism was used for genotyping and detection. Results: There was a difference in the frequencies of genotypes of FceRIb subunit int 2 in allergic rhinitis patients and controls. The FceRIb subunit int 2 gene polymorphism was found to be associated with allergic rhinitis in the Polish cohort. Conclusion: The results indicate that genetic factors may play an important role in the allergic rhinitis development in the investigated group.
Authors and Affiliations
Barbara Korzycka-Zaborowska, Hanna Zielińska-Bliźniewska, Jarosław Miłoński, Jurek Olszewski
Keywords
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