High Level Aminoglycoside Resistant Pattern of Enterococci Isolated from Urine at Tertiary Care Hospital
Journal Title: Scholars Journal of Applied Medical Sciences - Year 2018, Vol 6, Issue 6
Abstract
Abstract: UTIs constitute the most common type of disease produced by Enterococcus spp. Enterococci with high level resistance to aminoglycosides (HLAR), beta lactamase production & glycopeptide resistance including vancomycin resistance are posing a great therapeutic challenge, not only for clinicians but also for healthcare institutions. Therefore we conducted the study to find out prevalence of drug resistance in Enterococcal isolates with regards to HLAR (HLSR & HLGR) and Vancomycin resistance in our set up. Enterococcus isolated from all urine samples received in bacteriology section, from various wards was identified and speciated. Antibiotic susceptibility testing of isolated strains of enterococcus was done by Kirby baeur disk diffusion method, CLSI 2015.HLAR detection in enterococcus was done by disk diffusion method and Vancomycin MIC testing was done by E-test method. In our study, species isolated were E.faecalis and E.faecium, E. faecalis was predominant species (96%) followed by E. faecium (4%). High level gentamicin resistance (HLGR) were seen in 50% of all enterococcal isolates and High level streptomycin resistance (HLSR) was seen in 46% of isolates. HLGR was seen in 100% E. faecium isolates and in 47.9% of E. faecalis isolates. HLSR was seen in 50% E.faecium and 45.8% E.faecalis. High level of resistance was observed against ciprofloxacin and penicillin. 100% Vancomycin sensitivity was seen as tested by E-strip MIC test method. The synergistic effects obtained by combination of aminoglycoside with penicillin or vancomycin disappear in strains that show HLR to former. Therefore it is important to identify enterococcal species and HLR pattern correctly.
Authors and Affiliations
Sneha Mohan, Shalini Bisht, Anjali Agarwal, Vichal Rastogi
Keywords
Related Articles
- EP ID EP475809
- DOI -
- Views 57
- Downloads 0
Study of Variations in the Formation of Portal Vein
Portal vein is formed by union of superior mesenteric vein and splenic veins behind the neck of pancreas in front of inferior vena cava and at the level of L2 vertebra. Embryologically portal vein is formed by the select...
Tuberculosis of the Penis – A Rare Case
Tuberculosis of penis is extremely rare, comprising <1% cases of genital tuberculosis in male patients. It can be primary or secondary. Tuberculosis of penis presents as superficial ulcer or small nodule on the glans or...
A Study of Clinical and Surgical Management of Diabetic Foot
Abstract: A sum of 50 patients with diabetic feet was treated between 2014 and 2016. Wound progress was measured using a digital scanner. Limb salvage procedures like incision and drainage, debridement, slough excision a...
Evaluation of Inhaler Technique among Patients with Obstructive Airway Diseases – An Observational Study
Abstract: Both asthma and COPD caused significant morbidity and mortality worldwide. Mainstay treatment for both the diseases includes inhalation therapy. But majority of the patients do not use inhalers properly resulti...
Prevalence of HIV and HBV infection among Voluntary Blood donors at a tertiary care hospital, Vijayawada: A 5 year retrospective study
Human Immunodeficiency virus type 1 (HIV-1) and Hepatitis B virus (HBV) exact a high toll worldwide. Both can lead to chronic disease, cancer and death, and neither can be eradicated with the use of current therapies. Th...