High Level Aminoglycoside Resistant Pattern of Enterococci Isolated from Urine at Tertiary Care Hospital
Journal Title: Scholars Journal of Applied Medical Sciences - Year 2018, Vol 6, Issue 6
Abstract
Abstract: UTIs constitute the most common type of disease produced by Enterococcus spp. Enterococci with high level resistance to aminoglycosides (HLAR), beta lactamase production & glycopeptide resistance including vancomycin resistance are posing a great therapeutic challenge, not only for clinicians but also for healthcare institutions. Therefore we conducted the study to find out prevalence of drug resistance in Enterococcal isolates with regards to HLAR (HLSR & HLGR) and Vancomycin resistance in our set up. Enterococcus isolated from all urine samples received in bacteriology section, from various wards was identified and speciated. Antibiotic susceptibility testing of isolated strains of enterococcus was done by Kirby baeur disk diffusion method, CLSI 2015.HLAR detection in enterococcus was done by disk diffusion method and Vancomycin MIC testing was done by E-test method. In our study, species isolated were E.faecalis and E.faecium, E. faecalis was predominant species (96%) followed by E. faecium (4%). High level gentamicin resistance (HLGR) were seen in 50% of all enterococcal isolates and High level streptomycin resistance (HLSR) was seen in 46% of isolates. HLGR was seen in 100% E. faecium isolates and in 47.9% of E. faecalis isolates. HLSR was seen in 50% E.faecium and 45.8% E.faecalis. High level of resistance was observed against ciprofloxacin and penicillin. 100% Vancomycin sensitivity was seen as tested by E-strip MIC test method. The synergistic effects obtained by combination of aminoglycoside with penicillin or vancomycin disappear in strains that show HLR to former. Therefore it is important to identify enterococcal species and HLR pattern correctly.
Authors and Affiliations
Sneha Mohan, Shalini Bisht, Anjali Agarwal, Vichal Rastogi
Keywords
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