High Sensitivity Troponin T Level and Cardiovascular Performance in Patients with Liver Cirrhosis
Journal Title: International Journal of Medical Research Professionals - Year 2017, Vol 3, Issue 3
Abstract
Introduction: Cirrhotic cardiomyopathy is a new entity reported in patients with advanced liver cirrhosis. High sensitivity cardiac troponin T (hs-cTnT) is a biological marker specifically derived from the cardiac muscle. Recent data suggest that cardiac troponins are valuable for screening asymptomatic individuals for subclinical cardiovascular disease. Objective: To evaluate hs-cTnT level in post hepatitis C cirrhotic patients and correlating the results with severity of liver disease, carotid intima media thickness (CIMT) and cardiac performance. Methods: The study involved 40 cirrhotic patients without established cardiovascular diseases in addition to 20 apparently healthy volunteers serving as control. Demographic details, clinical data, laboratory data, echocardiographic study of left ventricular systolic and diastolic function, abdominal ultrasonography, ECG, and B-Mode Carotid ultrasonography for evaluation of CIMT were obtained. Sera were collected for measurement of high sensitivity troponin T levels. Correlations of hs-cTnT level with echocardiographic parameters, Child-Pugh functional scoring of cirrhosis as well as with abdominal ultrasound and laboratory parameters were investigated. Results: There was a highly statistically significant increase in hs-cTnT level in patient group compared to control group. We found a positive correlation between hs-cTnT level and portal vein diameter, serum K, Child-Pugh Score, corrected QT interval in ECG, left ventricular mass, interventricular septal diameter, peak velocity of atrial filling A and CIMT. There was a negative correlation between hs-cTnT level and liver diameter, serum sodium, serum albumin and echocardiographic E/A ratio. Conclusion: Elevated hs-cTnT in cirrhotic patients can be one of the tools used for early diagnosis of subclinical cirrhotic cardiomyopathy.
Authors and Affiliations
Ashraf Abd El-Khalik Barakat, Fatma Mohammad Nasr, Amna Ahmed Metwaly, Amal I. Sabry, Mona Hassan
Keywords
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- EP ID EP547783
- DOI 10.21276/ijmrp.2017.3.3.012
- Views 99
- Downloads 0
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