High serum Matrix metalloproteinase- 9 level in patients with Essential hypertension
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2017, Vol 16, Issue 10
Abstract
Abstract: Arterial hypertension causes changes in vascular wall structure, vascular remodeling which leads to several complications such as hypertensive heart disease, aortic aneurysm, peripheral arterial disease, chronic kidney disease and retinopathy. Matrix metalloproteinase-9 (MMP-9), a type IV gelatinase (Collagenase-B) plays a major role in extracellular matrix degradation and has been implicated as an important factor in atherosclerosis and vascular remodeling. They are also involved in numerous processes such as inflammation, fibrosis, angiogenesis and cell apoptosis. Increased activity of MMP-9 is related to the development and progression of cardiovascular complications. C-reactive protein (CRP) was believed to be a marker of vascular inflammation and recent research indicates that it plays an active role in atherogenesis. It is detectable in the early stages of plaque development and involved throughout the atherogenic process. Hence we measured the serum MMP-9 and hs-CRP in hypertensive patients. Fifty cases of essential hypertension without any complications and twenty five normotensive, healthy controls were selected for the study. Baseline investigations, serum MMP-9 and hs-CRP level were analyzed. We observed that hypertensive subjects showed significantly elevated MMP-9 level in comparison with normotensive control subjects. They also had significantly elevated hs-CRP levels indicating the presence of low grade inflammatory process. High serum MMP-9 and hsCRP levels indicate the inflammatory process in spite of antihypertensive drugs and so there is risk for cardiovascular complications in hypertensive subjects.
Authors and Affiliations
Vasanthi. R, Santha. K, Periyasamy. S, Sethupathy. S
Keywords
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- EP ID EP244864
- DOI 10.9790/0853-1610155052
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