High sucrose diet feeding aggravates age related changes in oxidative stress and antioxidant status of WNIN/Gr-Ob obese rats
Journal Title: International Journal of Medical and Health Sciences - Year 2017, Vol 6, Issue 3
Abstract
Background: Ageing is a multifactorial process in which physical and physiological changes accumulate over time, leading to gradual deterioration and death. Obesity and T2DM (Type 2 Diabetes Mellitus) per se accelerate ageing but the underlying mechanisms are not clear yet, nor it is known whether superimposing T2DM on obesity accelerates ageing further. The present study validated the hypothesis, “Induction of T2DM in obese rats by feeding high sucrose diet accelerates ageing by aggravating oxidative stress and / or compromising the antioxidant status ". Materials and Methods: WNIN/Gr-Ob rats, an established obese rat model was fed with high sucrose diet for the induction of T2DM / aggravated insulin resistance (IR), a pre-diabetic condition. Oxidative stress and antioxidant markers were determined in the liver homogenates by spectrophotometric methods. Results: Induction of T2DM / aggravation of insulin resistance (IR) in WNIN/Gr-Ob obese rats by feeding High Sucrose Diet (HSD) significantly increased tissue oxidative stress (protein carbonyls) and decreased antioxidant status: enzymatic (superoxide dismutase and catalase) and non-enzymatic (reduced glutathione) after six months of feeding, as compared to those of control rats fed starch based diet (SBD). Conclusion: Taken together with our recent report of aggravated insulin resistance, increased DNA damage and decreased telomere length in the brains of HSD fed obese rats, the present findings suggest that feeding HSD aggravated ageing associated systemic oxidative stress perhaps due to impaired anti oxidant status and may underlie the aggravated insulin resistance, which in turn accelerated their ageing.
Authors and Affiliations
Aruna Potukuchi, Uma Addepally, Malathi Upadrashta, Balakrishna Nagalla and Raghunath Manchala
Keywords
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