High sucrose diet feeding aggravates age related changes in oxidative stress and antioxidant status of WNIN/Gr-Ob obese rats
Journal Title: International Journal of Medical and Health Sciences - Year 2017, Vol 6, Issue 3
Abstract
Background: Ageing is a multifactorial process in which physical and physiological changes accumulate over time, leading to gradual deterioration and death. Obesity and T2DM (Type 2 Diabetes Mellitus) per se accelerate ageing but the underlying mechanisms are not clear yet, nor it is known whether superimposing T2DM on obesity accelerates ageing further. The present study validated the hypothesis, “Induction of T2DM in obese rats by feeding high sucrose diet accelerates ageing by aggravating oxidative stress and / or compromising the antioxidant status ". Materials and Methods: WNIN/Gr-Ob rats, an established obese rat model was fed with high sucrose diet for the induction of T2DM / aggravated insulin resistance (IR), a pre-diabetic condition. Oxidative stress and antioxidant markers were determined in the liver homogenates by spectrophotometric methods. Results: Induction of T2DM / aggravation of insulin resistance (IR) in WNIN/Gr-Ob obese rats by feeding High Sucrose Diet (HSD) significantly increased tissue oxidative stress (protein carbonyls) and decreased antioxidant status: enzymatic (superoxide dismutase and catalase) and non-enzymatic (reduced glutathione) after six months of feeding, as compared to those of control rats fed starch based diet (SBD). Conclusion: Taken together with our recent report of aggravated insulin resistance, increased DNA damage and decreased telomere length in the brains of HSD fed obese rats, the present findings suggest that feeding HSD aggravated ageing associated systemic oxidative stress perhaps due to impaired anti oxidant status and may underlie the aggravated insulin resistance, which in turn accelerated their ageing.
Authors and Affiliations
Aruna Potukuchi, Uma Addepally, Malathi Upadrashta, Balakrishna Nagalla and Raghunath Manchala
Keywords
Related Articles
- EP ID EP40023
- DOI -
- Views 237
- Downloads 0
Total serum Bilirubin level in men with Coronary Artery Disease
Background: Low total bilirubin (TB) has been shown to be inversely related to Coronary artery disease (CAD). Aims: To study the association of TB with CAD [acute myocardial infarction (AMI) and chronic stable angina (C...
A cross sectional study on prevalence of health problems in women of reproductive age group in an urban slum area of South India
Introduction: In developing countries, mothers and children constitute approximately 70% of the total population. In India, 19% of the total population is constituted by women of the child-bearing age (15-44 years) .Wom...
Eventration of Right Hemidiaphragm With Gastric Volvulus
Eventration of right hemidiaphragm is an extremely rare condition. We report a case of eventration of right hemidiaphragm with gastric volvulus in a child presenting as respiratory illness. There were no symptoms relate...
Clinical Profile and Surgical Outcome of Abdominal Tuberculosis –A Retrospective Analysis
Background and objectives: Tuberculosis can present in varied forms and clinical manifestations. The primary objective of this study was to understand the clinical profile, demography, presentations and complications of...
Haematological Parameters in Female Breast Cancer Patients in South Western Nigeria
This is a cross sectional study of age and variations of Haematological parameters among female breast cancer patients and apparently healthy individuals in South western Nigeria.. Eighty eight breast cancer patients fr...