HISTOENDOCRINOLOGICAL CHANGES INDUCED BY STRESS IN THYROID GLAND OF ALBINO RATS
Journal Title: Journal of Evolution of Medical and Dental Sciences - Year 2019, Vol 8, Issue 6
Abstract
BACKGROUND The separation of Psychology from the premises of Biology is purely artificial, as the human psyche lives in dissoluble union with the body. Bodily changes are brought about by mental stimuli and emotions as effectively as bacteria and toxins.(1) Psychological changes can disturb the function of any organ and bring about somatic manifestations, the neuroendocrine effects of stress are mediated by hypothalamus (May field 1980)(2) as it serves as a transducer that translates higher neural activity into physiological responses, as on thyroid gland, it causes increase in T3 levels, variable changes in T4 levels and brings about significant histological changes. MATERIALS AND METHODS A Non Randomized Controlled Study was done in 60 albino rats, divided into 3 groups of 20 each with ten males and ten females in each group, Histology of thyroid gland was studied after processing and staining with H &E Stain, Masons and trichome stain, in immobilized rats for different durations, (Immobilization stress was chosen as it is not physically painful to rats and served as both physical and psychological stressor) maximum up to 3 months as control, test and diazepam treated groups, animals were sacrificed and blood for hormonal estimation was collected by decapitation. Observations- study revealed bigger thyroidal follicles with high cuboidal epithelium, cytoplasm getting basophilic from eosinophilic presence of vacuoles and variable increase in T3 and T4 levels, all in favour of cellular hypertrophy and hyperplasia. RESULTS Significant increase found in escape behaviour and aggressiveness of the animal, histological changes were in favour of hypertrophy and hyperplasia, increase in T3 and T4 levels were observed, diazepam partially antagonized the effect of stress on all the parameters observed. CONCLUSION Immobilisation stress causes hyper activity of thyroid gland in form of follicular hyperplasia and cellular hypertrophy and significant increase in T4 levels, diazepam partially antagonized the effect of stress on all the parameters observed.
Authors and Affiliations
Vandana Tewari, Samarjeet Kaur, Srivastava R. K.
Keywords
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- EP ID EP554772
- DOI 10.14260/jemds/2019/83
- Views 82
- Downloads 0
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