Histogenesis of developing human liver in Marathwada region of Maharashtra
Journal Title: Indian Journal of Clinical Anatomy and Physiology - Year 2016, Vol 3, Issue 3
Abstract
Pediatric liver transplants accounting for 10-15% of all liver transplants worldwide occur due to congenital defects. The main etiological factors behind liver transplantation are congenital liver defect. The American Liver Foundation published a ‘Pediatric Liver Research Agenda which advocate that a better understanding of embryonic liver development would provide important insights into treatment and preventive strategies for pediatric liver disease. The present study aims to see the detail histogenesis and development of human liver in prenatal period . Microscopic structure of liver at various gestational age groups. The size of hepatic lobule with the help of micrometer scale and eyepiece reticle. Total 40 human fetuses (19 male and 21 female) were procured from Obstetric/Gynaecology department of GMC Aurangabad. Consent was taken from respective parents with approval of Institutional Ethical Committee of GMC Aurangabad. The size of classical liver lobule was measured by using micrometer scale and the eyepiece reticle. After passing through different stages of staining, the slides were prepared from the liver tissue in which haemopoiesis was found abundant at early stages of gestation and decrease as the age of liver advances from 12th to 36th week of gestation. Connective tissue elements increase from 12th week onwards showing thick capsule and thickened trabeculae. Portal tracts start appearing from 18th week of gestation. Kupffer’s cell appears at around 22nd week of gestation and thereafter a gradual rising pattern is found up to 34th week of gestation. Portal triad are seen distinct by 22nd week of gestation therefore the hepatic lobule size can be measurable from 22nd week onwards. In our study the size of the hepatic lobule at 22nd week of gestation is 0.715 mm. The size of hepatic lobule then increases gradually up to 36th week of gestation and is 1.244 mm.
Authors and Affiliations
Mohammed Mujahid Ansari, Anjalee G. Ovhal, Shyam Sunder Rao
Keywords
Related Articles
- EP ID EP242714
- DOI -
- Views 75
- Downloads 0
Study of serum lipids as atherogenic risk factor in preclinical diabetes
Introduction and Objective Preclinical diabetes has been associated with cardiovascular morbidity and mortality in Indian population The current study was conducted to screen out preclinical diabetes impaired fasting gly...
Anatomical study of right coronary artery and its variations – Cadaveric study
Introduction: Knowledge of the normal and variant anatomy and anomalies of coronary circulation are vital component in the management of coronary artery disease. Any coronary artery disorder may reduce the blood supply t...
Study of anaemia amongst OPD patients visiting a private medical college in Lucknow, Uttar Pradesh
Introduction Anaemia is multi factorial with widespread negative consequences on health It is more common in developing countries It has a negative influence on the social and economic development of countryMaterials and...
Effect of Bhastrika Pranayama on respiratory muscle function
Introduction: Respiratory muscles improve their function in response to training. Yogic exercises have the ability to enhance respiratory efficiency. Respiratory training techniques have consistently demonstrated positiv...
Multicentric morphometric study of sexual dimorphism in body of first sacral vertebra of dry human sacra in Central India region
Human skeleton and its remains are important material for racial genetic anthropological and forensic investigations Sacrum being the last skeletal remains proves important in sex determination amp identification of dece...