Study of serum lipids as atherogenic risk factor in preclinical diabetes
Journal Title: Indian Journal of Clinical Anatomy and Physiology - Year 2018, Vol 5, Issue 3
Abstract
Introduction and Objective Preclinical diabetes has been associated with cardiovascular morbidity and mortality in Indian population The current study was conducted to screen out preclinical diabetes impaired fasting glycemia and impaired glucose tolerance and assess serum lipids as atherogenic risk factor for future cardiovascular complications We compared serum lipids in subjects with IFG and IGT to find out the high risk population so that early interventions can be done to prevent future cardiovascular morbidity and mortalityMaterials and Methods 200 nondiabetic apparently healthy subjects were selected for the study 75g oral Glucose tolerance test GTT was performed in all of them plasma glucose levels were estimated by GODPOD method Based on criteria by American Diabetic Association they were divided in four groups Group I Normal fasting GlucoseNormal glucose tolerance NFGNGT n70 Group II isolated Impaired fasting glucose iIFG n34Group III isolated Impired glucose tolerance iIGT n38 Group IV Impaired fasting glucose and IGTIFGIGT n54Serum cholesterol Triglycerides and HDL were estimated in the morning fasting samples from all the subjects and compared among the groupsResults The current study showed that Serum LDL and Triglycerides were significantly higher and serum HDL is significantly lower in prediabetic subjects iIGT iIGT IFGIGT when compared with Control subjects NFGNGT Also Serum LDL was significantly higher in those with iIGT and IFGIGT as compared to those with iIFG thus increasing atherogenic risk in iIGT subjects Also it was observed that Serum LDL TG and HDL do not show significant changes between those having iIGT and IFGIGT Also these levels were comparable in those with iIFG and NGT A positive correlation is also found between serum lipids and other known cardiovascular risk factors like BMI Systolic blood pressure and Rate pressure product in prediabetic subjectsConclusion This suggested that iIGT subjects having raised LDL TG and low HDL were at a higher risk of atherogenesis and future coronary heart diseases CHD hence can be targeted for early dietery lifestyle and pharmacological interventions to prevent future risk of CHDKeywords Impaired fasting glycemia IFG Impaired glucose tolerance IGT Low density lipoprotein LDL Triglycerides TG High density Lipoprotein HDL Coronary Heart Disease CHD
Authors and Affiliations
Mukesh R Dinkar, Alpna Mathur, Bharat H Patel
Keywords
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- EP ID EP476082
- DOI 10.18231/2394-2126.2018.0074
- Views 44
- Downloads 0
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