HISTOLOGICAL STUDY OF BLOOD VESSEL WALL FIBROSIS IN VARICOSE VEINS
Journal Title: Journal of Evolution of Medical and Dental Sciences - Year 2019, Vol 8, Issue 9
Abstract
BACKGROUND Varicose veins affect around 10% of the population, various theories have been postulated about the pathophysiology of the varicose veins. Vessel wall fibrotic changes and subsequent valvular incompetence is the underlying mechanism of varicose vein pathophysiology, whether this occurs as a result of venous hypertension or as a primary change is a matter of extensive clinical research. Various genetic studies have found association with deficiency/overactivity of tissue re-modelling factors as a cause of varicose veins. Our study aims to identify the chronic inflammatory changes in the vessel wall occurring in varicose veins and identifying the primary underlying pathology. The aim of this study was histopathological analysis of blood vessel wall fibrosis in varicose veins. MATERIALS AND METHODS Those patients with doppler proven saphenofemoral junction incompetence admitted in department of General Surgery in MVJ Medical College and Research Hospital who are undergoing Trendelenburg’s surgery satisfying the inclusion criteria were selected. RESULTS 62% of the subjects showed significant fibrotic changes in the vessel wall. Patients with first degree relatives who had varicose veins (71%) showed statistically significant fibrotic changes in the vessel wall. Patients who were overweight or obese showed statistically significant fibrotic changes in the vessel wall. Co-morbidities like Hypertension, Diabetes Mellitus and CAD showed no significant association to the pathology. Addictions like alcoholism, smoking had no significant association, however tobacco chewing showed significant pathological association. CONCLUSION Chronic inflammation of the vessel wall in varicose veins can cause valvular incompetence. Extensive clinical study with assessment of genetic markers and tissue remodelling factors is required to establish the aetiology as an epiphenomenon.
Authors and Affiliations
Anjani M. Reddy, Raja Parthiban, Mohamed Hamza A, Mohan Kumar R
Keywords
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- EP ID EP555042
- DOI 10.14260/jemds/2019/121
- Views 72
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