Histomorphologic Spectrum in Hyaline Vascular Variant of Castleman Disease
Journal Title: Journal of Clinical and Diagnostic Research - Year 2017, Vol 11, Issue 8
Abstract
Introduction: Castleman Disease (CD) is a rare lymphoproliferative disorder with heterogenous clinical and pathological features. It is a rare disease with mention in the rare disease data of the orphanet. It can present as unicentric or multicentric disease. Hyaline vascular variant and plasma cell variant are the two pathological subtypes. Hyaline vascular variant accounts for nearly 80% to 90% of unicentric cases. Hyaline vascular subtype variant has follicular and stroma rich subtype. Aim: To study the histomorphologic spectrum of hyaline vascular variant of CD. Materials and Methods: Retrospective cross-sectional, observational study was undertaken from the archival data between January 2009 and April 2015. Only ten cases of hyaline vascular CD were identified after studying the histomorphological characteristics. Both follicular and interfollicular changes were studied in detail. Results: The age of presentation ranged from 17 years to 59 years. Seven out of 10 cases were female. Site of presentation included cervical, inguinal, retroperitoneal, intra-abdominal and axillary. Six cases showed predominant follicular change. Two cases were sclerotic subtype. Two cases showed both follicular and interfollicular changes in equal proportion. Distribution of follicles throughout the lymphnode was seen in eight cases. Uniform sized follicles seen in seven out of ten cases. Small germinal centre with lymphocyte depletion was one of the uniform features seen in all 10 cases. Numerous high endothelial vessels were seen in nine cases. Twinning of germinal centre was seen in two cases. All ten cases showed concentric rings of small lymphocytes. Lollipop pattern was relatively rare feature seen in only two cases. Conclusion: Hyaline vascular variant of CD has considerable morphologic variation with few consistent features seen in most of the cases.
Authors and Affiliations
Chaithra Gowthuvalli Venkataramana, Hema Kini, Debarshi Saha, Sharada Rai, Deepa Sowkur Anandarama Adiga, Ranjitha Rao, Cheryl sarah philipose
Keywords
Related Articles
- EP ID EP358186
- DOI 10.7860/JCDR/2017/29415.10326
- Views 48
- Downloads 0
Spontaneous Intraperitoneal Bladder Rupture: A Rare Case Report
ABSTRACT Spontaneous Rupture of Urinary Bladder (SRUB) is an extremely atypical case (reported incidence of 1:126000) presenting to the emergency as an acute abdomen with other non-specific symptoms leading to high rates...
Concomitant Pulmonary Embolism and Acute Renal Failure in a Patient Undergoing Head Neck Surgery: A Case Report and Review of Literature
Surgical interventions for malignant neoplasms of the head and neck region bear a risk of general medical complications. Venous thromboembolism and pulmonary embolism is closely tied to patients suffering from carcinoma...
Comparative Study on Antenatal and Perinatal Outcome of Vivax and Falciparum Malaria in a Tertiary Care Hospital of Kolkata, India
Introduction: Malaria occurring in pregnancy is associated with considerable maternal and perinatal morbidity. In India, the problem is compounded by dual parasitological aetiology of Plasmodium vivax (P. vivax) and Plas...
Moringa oleifera Leaf Extract: Beneficial Effects on Cadmium Induced Toxicities - A Review
Environment has been contaminated by heavy metals ever since the original magma of earth has solidified. One such toxin is cadmium. Cadmium that has been around since the industrial age, is considered hazardous both to u...
Prevalence of Asymptomatic Atherosclerotic Plaque at Carotid Bifurcation in Individuals of 20-70 years of Age
ABSTRACT Introduction: Stroke is the second most common cause of death worldwide. Among 20-30% of all ischaemic infarcts are caused by carotid artery stenosis. Computed Tomography Angiography (CTA), Magnetic Resonance An...