HISTOMORPHOLOGICAL ANALYSIS OF MIXED BAG OF MEDIASTINAL LESIONS IN A TERTIARY CARE CENTRE
Journal Title: Journal of Evolution of Medical and Dental Sciences - Year 2018, Vol 7, Issue 16
Abstract
BACKGROUND Mediastinum is a Pandora’s box consisting of variety of non-neoplastic and neoplastic lesions, which present as masses. Aims and Objectives- The purpose of this study is to emphasise the role of CT-guided Tru-Cut biopsy in early diagnosis of mediastinal lesions. MATERIALS AND METHODS This was a retrospective descriptive study of the histopathological spectrum of the primary mediastinal lesions in a tertiary care hospital between January 2011 and May 2015. Relevant clinical and radiological details were obtained for each case. Histological examination of the true-cut biopsies and resected specimens was carried out followed by immunohistochemistry for confirmation whenever necessary. RESULTS Of the 32 cases included in the present study, nineteen cases showed lesions in the anterior, five in the posterior and eight in the middle mediastinum. Most of these patients were in the 2nd decade of life with male preponderance. All these mediastinal lesions were categorised into benign (46.9%), malignant (43.75%) and inflammatory (9.37%), of which the most common malignant lesion was lymphoma (37.5%) followed by thymoma (28.13%) and germ cell tumour (6.25%). Tuberculosis (6.25%) was the commonest inflammatory lesion. The most common lymphoma was nodular sclerosis Hodgkin lymphoma (58.33%) and among the thymomas, it was type AB thymoma (44.44%). Thymic tuberculosis, extragonadal thymic germinoma and mediastinal immature teratoma with vascular proliferation were the rare lesions included in this study. The sensitivity and specificity of this study were 72.72% and 75% respectively. CONCLUSION The CT-guided Tru-Cut biopsy is an early diagnostic tool in the evaluation of various mediastinal lesions.
Authors and Affiliations
Prajna K Shetty, Pranveer Singh Rao, Muktha R Pai, Meghashree V
Keywords
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- EP ID EP414628
- DOI 10.14260/jemds/2018/445
- Views 77
- Downloads 0
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