HISTOMORPHOMETRIC ANALYSIS IN KIDNEY TISSUE OF MICE TREATED WITH INDIGOFERA SUFFRUTICOSA MILL
Journal Title: International Journal of Pharmacy and Pharmaceutical Sciences - Year 2015, Vol 7, Issue 9
Abstract
Objective: To investigate by histomorphometry the effect of aqueous extract of Indigofera suffruticosa leaves on proximal convoluted tubules and renal corpuscles of mice with sarcoma 180.Methods: Male swiss albino mice (Mus musculus) with 60 days of age were divided into 3 groups of 6 animals: Group 1-sarcoma 180 treated with aqueous extract (50 mg/kg, intraperitoneally (i. p.)), Group 2-sarcoma 180 treated with saline solution (15 ml/kg, i. p.) and Group 3–without sarcoma 180 treated with saline (15 ml/kg, i. p.). After 48 hours of tumor implantation, the treatment was initiated during 7 days. Histomorphometric analysis of kidney tissue was performed using IMAGEJ software.Results: Antitumoral treatment with aqueous extract of I. suffruticosa leaves at a dose of 50 mg/kg has not caused mice renal tissue histological changes.Conclusion: After treatment with aqueous extract of leaves of I. suffruticosa, renal architecture was preserved, suggesting its safety use as an antitumor agent.Â
Authors and Affiliations
Marllon Alex Nascimento Santana, Ivanise Brito Da Silva, JÉssica AndrÉia Pereira Barbosa, Izabela Rangel Lima, Jeymesson Raphael Cardoso Vieira, Roberta Maria Pereira Leite Lima, SÔnia Pereira Leite
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