HISTOMORPHOMETRIC ANALYSIS IN KIDNEY TISSUE OF MICE TREATED WITH INDIGOFERA SUFFRUTICOSA MILL
Journal Title: International Journal of Pharmacy and Pharmaceutical Sciences - Year 2015, Vol 7, Issue 9
Abstract
Objective: To investigate by histomorphometry the effect of aqueous extract of Indigofera suffruticosa leaves on proximal convoluted tubules and renal corpuscles of mice with sarcoma 180.Methods: Male swiss albino mice (Mus musculus) with 60 days of age were divided into 3 groups of 6 animals: Group 1-sarcoma 180 treated with aqueous extract (50 mg/kg, intraperitoneally (i. p.)), Group 2-sarcoma 180 treated with saline solution (15 ml/kg, i. p.) and Group 3–without sarcoma 180 treated with saline (15 ml/kg, i. p.). After 48 hours of tumor implantation, the treatment was initiated during 7 days. Histomorphometric analysis of kidney tissue was performed using IMAGEJ software.Results: Antitumoral treatment with aqueous extract of I. suffruticosa leaves at a dose of 50 mg/kg has not caused mice renal tissue histological changes.Conclusion: After treatment with aqueous extract of leaves of I. suffruticosa, renal architecture was preserved, suggesting its safety use as an antitumor agent.Â
Authors and Affiliations
Marllon Alex Nascimento Santana, Ivanise Brito Da Silva, JÉssica AndrÉia Pereira Barbosa, Izabela Rangel Lima, Jeymesson Raphael Cardoso Vieira, Roberta Maria Pereira Leite Lima, SÔnia Pereira Leite
Keywords
Related Articles
- EP ID EP578493
- DOI -
- Views 42
- Downloads 0
ANTIBACTERIAL ACTIVITY OF ISOLATED ENDOPHYTIC FUNGI FROM RAUVOLFIA SERPENTINA (L.) BENTH. EX KURZ
Objective: The aim of the present study was to isolate the endophytic fungi from medicinal plant Rauvolfia serpentina (L.) Benth. ex Kurz. (Family Apocynaceae) and observed their antibacterial activity against bacteria a...
SPECTRAL STUDIES OF THE INTERACTION BETWEEN SOLIFENACIN SUCCINATE AND HERRING SPERM DNA
Objective: The interaction between solifenacin succinate (SFS) and herring sperm DNA (Hs-DNA) was investigated by using UV–vis and fluorescence spectra at pH 7.4.Methods: The UV-vis and fluorimetric titrations were per...
OSTEOPOROTIC FRACTURE RISK IN RHEUMATOID ARTHRITIS
Objective: Osteoporosis is an extra-articular complication of rheumatoid arthritis (RA) with increased risk of fractures. FRAX is an online tool for assessing risk of osteoporotic fracture. However, the relationship betw...
COMPARATIVE EVALUATION OF ANTIDIABETIC AND ANTIOXIDANT POTENCY OF DIFFERENT EXTRACTS OBTAINED FROM MEMECYLON SPECIES
Objective: Memecylon species is being extensively used in traditional medicine for the treatment of skin disorders and it is proved to possess antidiabetic and anti-inflammatory properties. The present investigation was...
DEVELOPMENT AND EVALUATION OF GASTRORETENTIVE FLOATING TABLETS OF A QUINAPRIL HCL BY DIRECT COMPRESSION TECHNIQUE
Objective: The present study was undertaken with an objective to design, develop and evaluate gastro retentive floating tablets of an antihypertensive drug, quinapril HCl, which release the drug in a sustained manner ove...