Histopathologic Spectrum of Prostatic Diseases and Prostate Specific Antigen Level
Journal Title: Indian Journal of Pathology: Research and Practice - Year 2019, Vol 8, Issue 1
Abstract
Aim: To delineate the histopathological pattern of prostate diseases and to correlate prostate speci c antigen values and histomorphological features. Methods and materials: A retrospective review was made of all prostate biopsy reports seen between January 2013 to December 2017 at Department of Pathology, Khaja Banda Nawaz Institute of Medical Sciences Kalaburagi, Karnataka. A total number of 164 biopsies was received at the department of pathology. All prostate biopsies were classi ed as In ammatory and neoplastic lesions which comprise benign prostatic hypertrophy and carcinoma. Prostate speci c antigen values were analyzed documented and correlated with histopathological ndings. Hematoxylin and eosin stained sections were examined using paraf n embedded blocks. Results: Mean age of presentation was 60.5±12.5yrs with maximum incidence in 7th decade of life. Out of 164 biopsies examined 85.97% (141cases) were diagnosed as benign prostatic hyperplasia with or with out prostatitis, Two cases were diagnosed as High grade Prostatic intraepithelial neoplasia [1.23%] and 21 cases were adenocarcinoma [12.80%]. The most common gleason score was 7 (71.42%) followed by score 9 (19.04%). and score 4 (9.52) .Pattern 4 was most common predominant. Most adenocarcinoma is well differentiated to moderately differentiate with Gleason’s score of 4 to 9. Prostate speci c antigen [PSA] is used as screening test for prostate carcinoma with PSA value in range from 4 to 140ng/ml. Conclusions: In this study, 1. Benign Prostatic hyperplasia is commonest benign lesion and adenocarcinoma is histopathological type of prostate cancer. 2. Prostate speci c antigen [PSA] was in higher range in prostate cancer than in Benign Prostatic hyperplasia, hence PSA is good early indicator for malignancy 3. Histopathology examination remains the diagnostic test for con rmation of malignancy
Authors and Affiliations
Mohd Irshad Ahmed
Keywords
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- EP ID EP596883
- DOI 10.21088/ijprp.2278.148X.8119.9
- Views 65
- Downloads 0
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