HISTOPATHOLOGICAL ANALYSIS OF SPLENECTOMY SPECIMENS IN A TERTIARY CARE HOSPITAL- A TWO-YEAR STUDY
Journal Title: Journal of Evolution of Medical and Dental Sciences - Year 2018, Vol 7, Issue 44
Abstract
BACKGROUND Splenectomy is a rare surgical procedure performed worldwide. It is performed as an emergency procedure, especially in cases of traumatic injury and as an elective procedure for other causes. Apart from primary pathology involving spleen, splenectomy is performed for other disorders like pancreatitis and malignancy of stomach when secondary involvement of spleen is suspected. Haematologic disorders, both malignant and non-malignant, are other important indications for splenectomy. Worldwide studies have shown that trauma (45 - 75%) is the leading cause of splenectomy in low income countries and during wars, while haematologic causes (20 - 35%) account for majority of splenectomy in high income countries. Very few studies have been carried out in India, especially South India to analyse splenectomy causes and histomorphology. Aim- This study is a two-year retrospective descriptive study done on splenectomy specimens received during September 2014 to August 2016 in the Pathology Department of Madras Medical College and Rajiv Gandhi Government General Hospital, Chennai. The aim of this study is to study the causes/ indications for splenectomy and to correlate the histomorphology with the clinical diagnosis. MATERIALS AND METHODS This is a retrospective descriptive study. All splenectomy specimens received during the two-year period from September 2014 to August 2016 were analysed. The splenectomy specimens were fixed in 10% buffered formalin, routinely processed and H and E sections were studied. Special stains and immunohistochemistry were done where necessary. RESULTS 90 cases of splenectomy were received in the study period. The causes and indications varied widely. Most common cause was trauma causing laceration of the spleen (47) (52.2%). Next cause was pancreatic pathology associated with splenomegaly (13) (14.4%). Other causes were portal hypertension with splenomegaly (7) (7.8%), hypersplenism (6) (6.7%), hereditary spherocytosis (5) (5.6%), splenic abscess (4) (4.5%), splenic cyst (3) (3.3%), (one of which turned out to be Lymphangioma of spleen), splenic artery pseudoaneurysm (3) (3.3%) and one case each of carcinoma stomach and eventration of diaphragm. CONCLUSION Splenectomy is indicated in a wide spectrum of disorders. Histopathological examination and its clinical correlation is useful in the management of these cases. It helps to study the pathology of spleen in various disorders ranging from trauma, haematologic disorders, portal hypertension and primary splenic lesions. This study highlights the wide variety of lesions encountered in splenectomy specimens including very rare conditions like epithelial cyst and lymphangioma of spleen.
Authors and Affiliations
Sudha Venkatesh, Padmavathi Rajagopalan, Geetha Devadas
Keywords
Related Articles
- EP ID EP549242
- DOI 10.14260/jemds/2018/1069
- Views 81
- Downloads 0
A COMPARATIVE STUDY OF ECHOCARDIOGRAPHIC PARAMETERS IN INDIAN PREGNANT AND NONPREGNANT WOMEN
BACKGROUND Pregnancy is a physiological stressful condition, which is accompanied by changes in cardiovascular parameters to fulfil the requirement of rapidly developing embryo and subsequent foetal growth. Serial evalua...
STEREOTACTIC COMPUTED TOMOGRAPHIC-GUIDED ASPIRATION AND THROMBOLYSIS OF INTRACEREBRAL HAEMATOMA
BACKGROUND Spontaneous intracerebral haemorrhage produces devastating neurological disability and is by far the most untreatable form of stroke. ICH is mainly managed medically. To date there are no studies to prove that...
GASTROINTESTINAL STROMAL TUMOUR – REVISITED
Although less common than epithelial neoplasms, mesenchymal tumours of GI tract are not rare. The main bulk of these mesenchymal tumours is formed by Gastrointestinal stromal tumors (GIST). However they are not...
VISA AMONGST MRSA ISOLATES IN A TERTIARY CARE HOSPITAL IN MANIPUR
BACKGROUND Methicillin-resistant Staphylococcus aureus (MRSA) is a major cause of hospital acquired and community-acquired infections. MRSA isolates are important for their resistance to many commonly used antibiotics. V...
ISOLATION AND IDENTIFICATION OF CANDIDA SPECIES IN THE PATIENTS OF UTI
Fungal infections of the urinary tract especially those caused by Candida species are becoming increasingly common due to prolonged antibiotic use, indwelling urinary catheters, and increase in the number of im...