Histopathological Changes in Gastric Mucosal Biopsies in Chronic Gastritis and Correlation of Pathological Features with Helicobacter Pylori Infection
Journal Title: Pathology Update: Tropical Journal of Pathology and Microbiology - Year 2015, Vol 1, Issue 1
Abstract
Introduction: Diseases related to gastric acid account for nearly one third of all health expenditure on gastrointestinal (GI) diseases. Evaluation of morphological features in chronic gastritis using updated Sydney system has not been systematically evaluated in India. So this study was done to interpret the histopathological changes in chronic gastritis using updated Sydney system and to correlate these pathological features with Helicobacter pylori (H. pylori) infection. Methods Gastric mucosal biopsies in a tertiary care centre in north India were evaluated using routine histopathological methods. Histopathological changes in patients with chronic gastritis were interpreted using updated Sydney system and correlated with H. pylori infection. Results: Chronic gastritis was seen in 89 cases. Histological grading of chronic gastritis was done by updated Sydney system. Chronic inflammation was present in 100% cases, neutrophilic activity in 39.33% cases, intestinal metaplasia in 7.87% cases, glandular atrophy in 12.36% cases and lymphoid follicles in 29.21% cases. H. pylori were identified in 50.56% cases of chronic gastritis. Association of H. pylori with pathological features in chronic gastritis was evaluated. The association of H. pylori with degree of chronic inflammation, neutrophilic activity and lymphoid aggregates was statistically significant. Conclusions: Histopathology should be performed in all cases of chronic gastritis. The updated Sydney classification provides an objective histological evaluation of chronic gastritis. The grade of chronic inflammation, neutrophilic activity and lymphoid follicles are significantly associated with H. pylori infection. So search for H. pylori should be initiated if neutrophils and lymphoid follicles are seen in the antral biopsies.
Authors and Affiliations
Poonam Sharma, Kuldeep Kumar Kaul, Manik Mahajan, Vijyant Singh Chandail, Kuldeep Goswami, Puneet Gupta
Keywords
Related Articles
- EP ID EP327186
- DOI 10.17511/jopm.2015.i1.03.
- Views 123
- Downloads 0
Evaluation of diagnostic accuracy of FNAC and correlation with histopathology in thyroid lesions
Aim: The aim of the study is to evaluate the accuracy of FNAC diagnosis in non neoplastic & neoplastic lesions of thyroid, and correlating with histopathological findings. Materials and Methods: This was a prospective st...
Clinico-pathological study of benign soft tissue tumors: a study from tertiary teaching hospital
Background: Aim of the study was to analyze the histopathological findings in various benign soft tissue tumors and to study its frequency distribution in relation to age, gender and anatomical site. Material and Method...
Nodular lymphoid hyperplasia: A thin grey zone between hyperplasia and Pathological aggregate
Introduction: The clinical-pathological characteristics of 12 patients with intestinal nodular lymphoid hyperplasia (NLH) are described with the aim to try and delineate between hyperplasia and pathological aggregate of...
FNAC study of thyroid lesions using the Bethesda system
Background: The most reliable, safe, cost-effective and accurate way to evaluate thyroid nodule is cytology, which has become the standard of care. As there is a 10% lifetime risk of developing a thyroid nodule, screenin...
Bacteriology of infected burn wounds in hospitals in and around Davangere
Introduction: Study was conducted to isolate and identify the aerobic bacterial flora in burn wound patients admitted in and around hospitals of Davanagere. It also includes knowing common microbial pathogen involved in...