Histopathological Evaluation of Duodenal Biopsies In Celiac Disease On The Basis of Marsh Classification And Its Correlation With IgA tTG Titer.
Journal Title: International Journal of Medical Science and Innovative Research (IJMSIR) - Year 2019, Vol 4, Issue 3
Abstract
Background: Celiac disease is also known as Celiac sprue or gluten sensitive enteropathy. Celiac disease is a genetically determined autoimmune like disorder induced by gluten, the storage protein of wheat and by similar protein found in barley and rye. It has a strong genetic background, as suggested clearly by studies on first degree relatives of Celiac patients, on twins and on HLA genes associated with the susceptibility for the disease. Methods: This study was hospital based study on 102 duodenal biopsy specimen coming to the Department of Pathology Sardar Patel Medical College & Associated group of Hospitals, Bikaner during the study period. The present study was undertaken to histopathological evaluation of duodenal biopsies in Celiac disease on the basis of Marsh classification and its correlation with IgA tTG titre Results: Mean tTG titer in grade I was 5.71±2.21, in grade II was 7.0±0, in grade IIIa was 56.40±38.17, in grade IIIb was 85.20±52.12 and in grade IIIc was 175.83±66.56. The tTG titer was increased with Marsh grading I to IIIc. The correlation between Marsh grading and tTG titer was found statistically significant (p-value 0.001). Conclusion- tTG titer was increased with higher Marsh grading i.e. from grade I to IIIc , so biopsy could be avoided in patients specially in children.
Authors and Affiliations
Vanita kumar
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