Histopathological study of developmental toxicity of Carbamazepine in the mice
Journal Title: International Research Journal of Applied and Basic Sciences - Year 2013, Vol 7, Issue 10
Abstract
Developmental toxicity is a structural or functional alteration, which interferes with normal growth, differentiation, and development. Carbamazepine is one of the most widely used antiepileptic drugs among women of childbearing age. Investigation of carbamazepine developmental toxicity for vital organs. The healthy pregnant females were divided into three groups. The (control) group received distilled water/day orally. Second and third group received 52.5, 65 mg/day of carbamazepine respectively by gastric gavage. Fetuses were delivered by hysterectomy on the 18th day of gestation. Each fetus was assessed for histopathological changes of liver, kidney and heart. Liver mice showed congestion, inflammation with areas of hydropic degeneration in second group and marked complete distortion of the hepatic cells and large areas of degeneration in third group. Kidney mice showed atrophy of glomeruli, degeneration of renal tubules in second group and complete distortion of glomeruli and renal tubules in third group. Cardiac mice showed loss of normal architecture, degeneration of the myocardial fibers in second group and marked widespread fragmentation and degeneration of myocardial fibers in third group. Histopathological changes of liver, kidney and heart due to Carbamazepine developmental toxicity represents as congenital anomalies of organs depending on overdose degree of carbamazepine.
Authors and Affiliations
Said Said Elshama| Forensic Medicine & Clinical Toxicology Department, Faculty of Medicine, Taif University, Suez Canal University. email:saidelshama@yahoo.com, Hosam Eldin Hussein Osman| Anatomy Department, Faculty of Medicine, Taif University, Al-Azhar University., Ayman El-Meghawry El-Kenawy| Pathology Department, Faculty of Medicine, Taif University, Menoufiya University.
Keywords
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