Histopathological study on the effects of oral administration of aqueous leaf extracts of cymbopogon citratus on the frontal cortex of male sprague dawley rats
Journal Title: Scientific Journal of Biological Sciences - Year 2012, Vol 1, Issue 3
Abstract
This investigation was to evaluate the histopathological effects of oral consumption of the aqueous leaf extract of Cymbopogon citratus on the frontal cortex of Sprague Dawley (SD) rats. Ten male SD rats weighing between 150-230g were used. The rats were randomly assigned into two groups designated as groups A and B. Group A served as the control group while group B was the treatment. 300 mg/kg body weight of the aqueous leaf extract of C. citratus was administered once daily for 14 consecutive days (14d) orally through a sterilized orogastric tube, while the control rats received equal volume of phosphate buffered saline (PBS). The rats were sacrificed 24 hours after the last administration. The frontal cortices were excised, fixed in 10% formol calcium for 18 hours and were processed for routine light microscopic study using Hematoxylin and Eosin (H&E) method. The histological findings revealed that the extract treated sections showed cytoarchitectural distortions ranging from neuronal degeneration, distortion, vacuolations and evidence of necrotic bodies while the sections from the rats in group B conform to normal histological profile. These findings suggest a deleterious and toxic effects of aqueous leaf extract of C. citratus on the frontal cortex of SD rats.
Authors and Affiliations
D. A. Adekomi*| Department of Anatomy and Cell Biology, Faculty of Basic Medical Sciences, Obafemi Awolowo University, Ile-Ife, Osun State, Nigeria., A. O. Adekeye| Department of Anatomy, College of Medicine and Health Sciences, Afe Babalola University, Ado Ekiti, Ekiti State, Nigeria., O. O. Ogedengbe| Department of Anatomy, College of Medicine and Health Sciences, Afe Babalola University, Ado Ekiti, Ekiti State, Nigeria., R. Y. Ibiyeye| Department of Anatomy, Faculty of Basic Medical Sciences, University of Ilorin, Ilorin, Kwara State, Nigeria.
Keywords
Related Articles
- EP ID EP1066
- DOI -
- Views 623
- Downloads 46
Occurrence of deoxynivalenol in cereals and cereal based products: a short review
During recentdecades, the contamination of cereal grains with toxic metabolites of Fusariumspecies has been increasingly documented. Deoxynivalenol (DON) is one of themost common trichothecene toxins produced by F. grami...
Hypolipidemic properties of bauhinia rufescens in alloxan-induced diabetic rats
The present investigation was aimed at evaluating the hypolipidemic properties of methanolic leaf extracts of Bauhinia rufescens (MLEBR) on alloxan-induced diabetic rats. Alloxan was injected intraperitoneally as a singl...
Genetic correlation between egg quality traits
Genetic correlation coefficients between egg quality traits were studiedusing fifty- six harco pullets raised under standard management practices. Theestimates were carried out at 22-week, 26-week, 30-week and 32-week of...
Effect of salinity on chickpea seed germination pre-treated with salicylic acid
Chickpea (Cicer arietinum L.) is known to be highly susceptible towards soil or water salinity, whose are the primary abiotic factors that limit growth and crop of this plant in Algeria. Therefore, more efforts are need...
Histological study of the effects of oral administration of datura metel on the visual system of male wistar rats
This study was carried out in order to elucidate some of the effects of oral administration of Cannabis sativa on the visual system of male Wistar rats as marker of toxicity using neurohistochemical study. 12 adult male...