HIV genotypes and molecular transmission networks among MSM with newly reported HIV infections in Dehong Prefectureï¼ Yunnan Province from 2010 to 2019
Journal Title: Shanghai Journal of Preventive Medicine - Year 2023, Vol 35, Issue 12
Abstract
ObjectiveThis study aimed to investigate the HIV genotypic subtypes and molecular transmission clusters among men who have sex with men ï¼MSMï¼ with newly reported HIV infections in Dehong Dai and Jingpo Autonomous Prefecture ï¼Dehong Prefectureï¼ï¼ Yunnan Provinceï¼ Chinaï¼ between 2010 and 2019. The study aimed to identify potential high-risk transmitters and provide reference data for screeningï¼ managementï¼ and intervention of infection sources.MethodsPlasma samples from newly reported HIV-positive MSM individuals in Dehong Prefecture between 2010 and 2019 were collected. The viral pol gene fragments were amplifiedï¼ sequencedï¼ and genotyped. Genetic distances ï¼GDï¼ between pairwise sequences were analyzed and calculated. MEGA 7.0 and Gephi were used for phylogenetic and molecular transmission network analysis.ResultsA total of 159 newly reported HIV infections among MSM were included in the studyï¼ with successful genotyping of 100 cases. Nine HIV-1 subtypes were identifiedï¼ with the most prevalent being CRF01_AE subtype ï¼52%ï¼ï¼ followed by CRF07_BC subtype ï¼31%ï¼ï¼ CRF55_01B subtype ï¼10%ï¼ï¼ and others ï¼7%ï¼. Cluster analysis revealed a total network access rate of 67%ï¼ forming three transmission clusters. CRF01_AE subtype formed two transmission clusters with 38 and 3 infected individualsï¼ while CRF07_BC subtypes formed one transmission cluster with 26 infected individuals. The transmission network within the CRF01_AE clusters exhibited a more complex relationship. Significant differences in educational level were observed between the two main transmission clusters.ConclusionThe predominant HIV subtypes among newly reported MSM cases in Dehong Prefecture between 2010 and 2019 were CRF01_AE and CRF07_BC. Significant cultural differences are observed between the main transmission clusters. Continued monitoring of genotypic subtypes and targeted interventions within transmission clusters are warranted.
Authors and Affiliations
DUAN Xing,LIANG Xinyue,WANG Jibao,YANG Jin,WANG Yikui,YANG Yulong,ZHOU Sujuan,YANG Tao,YANG Yuecheng,TANG Renhai,YE Runhua,DING Yingying,HE Na,DUAN Song,
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